MEK162
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Background and purpose Glioblastoma multiforme (GBM) is the most aggressive subtype of malignant gliomas, with an average…
Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No…
Purpose Though the efficacy of MEK inhibitors is being investigated in KRAS-mutant colorectal cancers (CRC), early clinical…
PurposeBinimetinib is a potent, selective MEK1/2 inhibitor with demonstrated efficacy against BRAF- and RAS-mutant tumors…
Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective…
Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple congenital…
9051 Background: The MAPK and PI3K pathways share common upstream activators and contribute to cell proliferation…
9029 Background: Clinical data indicate that combining a BRAF and a MEK inhibitor (BRAFi, MEKi) may be more effective than BRAFi…
220 Background: The RAS/RAF/MEK/ERK pathway plays a major role in cell growth and survival and is aberrantly activated in many…