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ARRY-438162

Known as: ARRY-162 
National Institutes of Health

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MEK162

Papers overview

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2017
2017
Mitogen-Activated Protein Kinases Inhibitors: Potential Therapeutic Agents for Cancer Cachexia
The MAPK kinases, MEK1 and MEK2, act downstream of RAS/RAF to induce ERK activation, thereby communicating input from growth… 
2014
2014
Abstract 743: Potent anti-tumor activity of the MEK1/2 inhibitor MEK162 in human non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (SCCHN) cell lines
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA BACKGROUND: MAPK pathway dysregulation is frequently seen… 
2010
2010
Abstract 3855: Investigation of the growth inhibitory activity of the MEK inhibitor ARRY-438162 in combination with everolimus in a variety of KRas and PI3K pathway mutant cancers
The RAS/RAF/MEK/ERK and PI3K signaling pathways are known to play key roles in cell growth, proliferation and survival. Targeted… 
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