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ME-344

Known as: mTOR1/2 Kinase Inhibitor ME-344 
An active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
&NA; Isoflavones isolated from members of the Fabaceae (primarily Leguminosae) family have been characterized for their… Expand
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2017
2017
SummaryBackground This multicenter, open-label, phase Ib study was designed to assess the safety, pharmacokinetics and… Expand
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2016
2016
ME-344 [(3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol] is a second-generation derivative natural product… Expand
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Review
2016
Review
2016
Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different… Expand
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2016
2016
The isoflavone ME-344 is a potent anti-cancer agent with preclinical and clinical efficacy in solid tumors. Yet, the mechanism of… Expand
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2015
2015
Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have… Expand
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2015
2015
BACKGROUND The current phase 1, open-label, dose escalation study was conducted to establish the safety, tolerability… Expand
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2013
2013
Background: ME-344 is a second generation isoflavone-derived drug candidate that causes caspase-independent cell death in… Expand
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2013
2013
ME-344, a second-generation derivative of a natural product isoflavone is being developed as a clinical candidate in small cell… Expand
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2013
2013
Background: Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite initial responsiveness to… Expand
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