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MDX-1203

Known as: Anti-CD70 ADC MDX-1203, Anti-CD70 Antibody-Drug Conjugate MDX-1203 
An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule… Expand
National Institutes of Health

Papers overview

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2015
2015
AbstractPurpose The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal… Expand
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2014
2014
2558 Background: BMS936561 is a fully human monoclonal anti-body conjugate targeting the CD70 transmembrane cell-surface protein… Expand
2013
2013
BACKGROUND MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The… Expand
2012
2012
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell… Expand
2010
2010
MDX-1203 is a human anti-CD70 antibody conjugated to a DNA alkylating cytotoxic Drug A. Drug A is an enzyme-activated prodrug… Expand
Highly Cited
2004
Highly Cited
2004
CD70, the cellular ligand of the TNF receptor family member CD27, is expressed transiently on activated T and B cells and… Expand
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Highly Cited
2000
Highly Cited
2000
CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought… Expand
Highly Cited
1998
Highly Cited
1998
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control… Expand
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Highly Cited
1998
Highly Cited
1998
The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals. Here… Expand
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Highly Cited
1994
Highly Cited
1994
The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor… Expand