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MDX-1203

Known as: Anti-CD70 ADC MDX-1203, Anti-CD70 Antibody-Drug Conjugate MDX-1203 
An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

BMS-936561

Broader (2)

ImmunoconjugatesIndoles

Papers overview

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2014
2014
A phase 1 multicenter open-label dose-escalation study of BMS-936561 (MDX-1203) in clear cell renal cell carcinoma (ccRCC) and B-cell non Hodgkin lymphoma (B-NHL).
2558 Background: BMS936561 is a fully human monoclonal anti-body conjugate targeting the CD70 transmembrane cell-surface protein… 
2012
2012
Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell… 
2012
2012
Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate
MDX-1203 is an antibody drug conjugate under clinical evaluation by Bristol-Myers Squibb. The antibody portion is MDX-1115, a… 
2010
2010
Abstract 2575: Activation of antibody drug conjugate MDX-1203 by human carboxylesterase
MDX-1203 is a human anti-CD70 antibody conjugated to a DNA alkylating cytotoxic Drug A. Drug A is an enzyme-activated prodrug… 
2010
2010
Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinaiting disease
Highly Cited
2000
Highly Cited
2000
Involvement of CD70–CD27 interactions in the induction of experimental autoimmune encephalomyelitis
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