MDX-1203

Known as: Anti-CD70 ADC MDX-1203, Anti-CD70 Antibody-Drug Conjugate MDX-1203 
An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2015
01219942015

Papers overview

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2015
2015
The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal antibody-drug… (More)
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2013
2013
BACKGROUND MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The… (More)
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2012
2012
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell… (More)
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2010
2010
Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T… (More)
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2009
2009
783 conjugate candidate, is a human anti-CD70 mAb linked to a prodrug form of CC-1065, an alkylating agent first isolated from… (More)
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2004
2004
CD70, the cellular ligand of the TNF receptor family member CD27, is expressed transiently on activated T and B cells and… (More)
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2000
2000
CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought… (More)
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Highly Cited
1998
Highly Cited
1998
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control… (More)
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1998
1998
The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals. Here… (More)
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1994
1994
The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor… (More)
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