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MDX-1203
Known as:
Anti-CD70 ADC MDX-1203
, Anti-CD70 Antibody-Drug Conjugate MDX-1203
An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
BMS-936561
Broader (2)
Immunoconjugates
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70
T. Owonikoko
,
A. Hussain
,
+8 authors
L. Cohen
Cancer Chemotherapy and Pharmacology
2015
Corpus ID: 20799503
AbstractPurpose The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal…
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2013
2013
Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications.
L. Thevanayagam
,
A. Bell
,
+11 authors
M. Srinivasan
Bioanalysis
2013
Corpus ID: 29188935
BACKGROUND MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The…
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2012
2012
Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.
F. Makino
,
J. Ito
,
+6 authors
H. Akiba
American Journal of Respiratory Cell and…
2012
Corpus ID: 36529499
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell…
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2010
2010
Abstract 2575: Activation of antibody drug conjugate MDX-1203 by human carboxylesterase
Dan Derwin
,
D. Passmore
,
+14 authors
V. Rangan
2010
Corpus ID: 72776119
MDX-1203 is a human anti-CD70 antibody conjugated to a DNA alkylating cytotoxic Drug A. Drug A is an enzyme-activated prodrug…
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2010
2010
Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinaiting disease
S. Yanagisawa
,
Naoya Takeichi
,
+4 authors
C. Koh
Brain Research
2010
Corpus ID: 34591979
2009
2009
Big oil bucks for algae
C. Sheridan
Nature Biotechnology
2009
Corpus ID: 205270805
Highly Cited
2000
Highly Cited
2000
Involvement of CD70–CD27 interactions in the induction of experimental autoimmune encephalomyelitis
A. Nakajima
,
H. Oshima
,
+5 authors
K. Okumura
Journal of Neuroimmunology
2000
Corpus ID: 19108117
Highly Cited
1998
Highly Cited
1998
Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction.
K. Agematsu
,
H. Nagumo
,
+7 authors
A. Komiyama
Blood
1998
Corpus ID: 43172275
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control…
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Highly Cited
1998
Highly Cited
1998
CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells.
H. Nagumo
,
K. Agematsu
,
+8 authors
A. Komiyama
Journal of Immunology
1998
Corpus ID: 11966927
The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals. Here…
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Highly Cited
1994
Highly Cited
1994
CD70 represents the human ligand for CD27.
R. Q. Hintzen
,
S. Lens
,
G. Koopman
,
S. Pals
,
H. Spits
,
R. V. van Lier
International Immunology
1994
Corpus ID: 22124264
The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor…
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