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The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal… Expand 2558 Background: BMS936561 is a fully human monoclonal anti-body conjugate targeting the CD70 transmembrane cell-surface protein… Expand BACKGROUND
MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The… Expand The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell… Expand MDX-1203 is a human anti-CD70 antibody conjugated to a DNA alkylating cytotoxic Drug A. Drug A is an enzyme-activated prodrug… Expand CD70, the cellular ligand of the TNF receptor family member CD27, is expressed transiently on activated T and B cells and… Expand CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought… Expand B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control… Expand The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals. Here… Expand The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor… Expand