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MDX-1203

Known as: Anti-CD70 ADC MDX-1203, Anti-CD70 Antibody-Drug Conjugate MDX-1203 
An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule… Expand
National Institutes of Health

Papers overview

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2015
2015
AbstractPurpose The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal… Expand
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2013
2013
BACKGROUND MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The… Expand
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2012
2012
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T-cell… Expand
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2010
2010
MDX-1203 is a human anti-CD70 antibody conjugated to a DNA alkylating cytotoxic Drug A. Drug A is an enzyme-activated prodrug… Expand
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2010
2010
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC MDX-1203 is a human anti-CD70 antibody conjugated… Expand
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Highly Cited
2004
Highly Cited
2004
CD70, the cellular ligand of the TNF receptor family member CD27, is expressed transiently on activated T and B cells and… Expand
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Highly Cited
2000
Highly Cited
2000
CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought… Expand
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Highly Cited
1998
Highly Cited
1998
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control… Expand
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1998
1998
The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals. Here… Expand
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Highly Cited
1994
Highly Cited
1994
The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor… Expand
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