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MDX-010

Known as: MDX 010, MDX-101, MDX010 
National Institutes of Health

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Broader (1)

ipilimumab

Papers overview

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2013
2013
Safety and efficacy of ipilimumab in melanoma patients who received prior immunotherapy on phase III study MDX010-020.
9050 Background: MDX010-020 was a phase III comparison of ipilimumab (Ipi), gp100 vaccine or the combination for advanced… 
2011
2011
18F-FDG PET/CT imaging of an anti-CTLA-4 antibody-associated autoimmune pancolitis
Review
2011
Review
2011
Overall survival (OS) in the management of pretreated patients with unresectable stage III/IV melanoma: A systematic literature review and meta-analysis.
8580 Background: Ipilimumab is the first treatment to show an OS benefit in a phase III trial (MDX010-20) compared with a gp100… 
2010
2010
Trial Heralding a ‘New Day’ for Melanoma Meets with Guarded Enthusiasm
Ipilimumab has being lauded as a monumental advance in the field of immuno-oncology. While the news is certainly promising… 
2009
2009
Down-staging of locally advanced prostate cancer with anti-CTLA-4 monoclonal antibody prior to radical prostatectomy.
e16103 Background: At present, androgen ablation (AA) therapy ± radiation therapy represents a first-line treatment for patients… 
2006
2006
Phase I/II Study of Ipilimumab (MDX-010), an Anti-CTLA-4 Monoclonal Antibody, in Patients with Follicular Non-Hodgkin Lymphoma.
Background: Follicular lymphoma is a B-cell malignancy in which tumor-immune system interactions have the potential to profoundly… 
2006
2006
Is tumor immunity the same thing as autoimmunity? Implications for cancer immunotherapy.
The immune system is capable of inducing tumor regression in selected patients, and the mechanisms regulating this process are… 
2006
2006
Analysis of Peripheral Blood CD4+/CD25high Treg Cells and FOXP3 mRNA Expression in Patients Treated with Ipilimumab (Monoclonal Human Anti-CTLA4, MDX-010) for Relapse of Malignancy Following…
CTLA-4 is expressed upon activation of T-cells,and serves as an important negative regulator of their effector function. It is… 
2004
2004
A phase II, randomized multi-center study of MDX-010 alone or in combination with dacarbazine (DTIC) in stage IV metastatic malignant melanoma.
7511 Background: MDX-010 is a human anti-CTLA-4 IgG1 monoclonal antibody that blocks CTLA-4 and augments immune responses. In… 
2004
2004
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody blockade in patients previously vaccinated with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony…
2536 Background: Vaccination with irradiated, autologous tumor cells engineered to secrete GM-CSF (GVAX) consistently stimulates… 
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