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MDM2 wt Allele

Known as: hdm2, Mouse Double Minute 2 Homolog Gene, p53-Binding Protein Gene 
Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein… 
National Institutes of Health

Related topics

Related topics

18 relations
12q14.3-q15ATM Signaling PathwayAndrogen Receptor Regulation PathwayAtypical Lipoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Small molecule protein-protein inhibitors for the p53-MDM2 interaction.
This article describes recent progress in the development of small molecule protein-protein inhibitors of the p53-MDM2 (purine… 
Highly Cited
2006
Highly Cited
2006
The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors
Purpose: The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations… 
Highly Cited
2006
Highly Cited
2006
Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription*
Mutational inactivation of p53 is only one of the ways that tumors lose p53 function. An alternate route is through… 
Highly Cited
2005
Highly Cited
2005
Significance of HDMX‐S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
The product of the HDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with… 
2003
2003
Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation.
Mdm2 and MdmX function as cellular regulators of the p53 tumor suppressor protein. Mdm2, a p53 inducible protein, negatively… 
Highly Cited
2001
Highly Cited
2001
HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.
We investigated the role of alterations of HDM2, the human homologue of murine mdm2, in the tumorigenesis and progression of… 
2001
2001
Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma*
The wild type p53 tumor suppressor protein is rapidly degraded in normal cells by MDM2, the ubiquitin ligase that serves as the… 
2001
2001
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Oncogenic alterations can influence tumor cell survival partly by affecting the activity of the hypoxia-inducible factor-1 (HIF-1… 
Highly Cited
2000
Highly Cited
2000
Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation
The activity of the tumor suppressor p53 is induced in response to DNA-damaging agents such as UV and γ radiation… 
2000
2000
Development of a binding assay for p53/HDM2 by using homogeneous time-resolved fluorescence.
The p53 tumor suppressor protein is activated and stabilized in response to DNA damage, resulting in cell cycle arrest or… 
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