Skip to search formSkip to main contentSkip to account menu

MDM2 wt Allele

Known as: hdm2, Mouse Double Minute 2 Homolog Gene, p53-Binding Protein Gene 
Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein… 
National Institutes of Health

Related topics

Related topics

18 relations
12q14.3-q15ATM Signaling PathwayAndrogen Receptor Regulation PathwayAtypical Lipoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Structural determinants of benzodiazepinedione/peptide-based p53-HDM2 inhibitors using 3D-QSAR, docking and molecular dynamics
As a tumor suppressor, p53 protein regulates the cell cycle and is involved in preventing tumorgenesis. The protein level of p53… 
Review
2007
Review
2007
Small molecule protein-protein inhibitors for the p53-MDM2 interaction.
This article describes recent progress in the development of small molecule protein-protein inhibitors of the p53-MDM2 (purine… 
Highly Cited
2006
Highly Cited
2006
The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors
Purpose: The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations… 
Highly Cited
2006
Highly Cited
2006
Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription*
Mutational inactivation of p53 is only one of the ways that tumors lose p53 function. An alternate route is through… 
Review
2005
Review
2005
Small molecule inhibitors of p53/MDM2 interaction.
The discovery of the key negative regulator MDM2 (mouse double minute 2, also termed HDM2 for its human equivalent) provided a… 
2004
2004
p53 and RB: simple interesting correlates or tumor markers of critical predictive nature?
Compared with the established phases a new drug must go through before regulatory approval and acceptance as part of a new… 
2003
2003
Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation.
Mdm2 and MdmX function as cellular regulators of the p53 tumor suppressor protein. Mdm2, a p53 inducible protein, negatively… 
Highly Cited
2001
Highly Cited
2001
HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.
We investigated the role of alterations of HDM2, the human homologue of murine mdm2, in the tumorigenesis and progression of… 
2001
2001
Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma*
The wild type p53 tumor suppressor protein is rapidly degraded in normal cells by MDM2, the ubiquitin ligase that serves as the… 
2001
2001
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Oncogenic alterations can influence tumor cell survival partly by affecting the activity of the hypoxia-inducible factor-1 (HIF-1… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)