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MDM2 wt Allele

Known as: hdm2, Mouse Double Minute 2 Homolog Gene, p53-Binding Protein Gene 
Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed, and newly diagnosed multiple myeloma… Expand
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Highly Cited
2006
Highly Cited
2006
Cellular senescence is a stable state of proliferative arrest that provides a barrier to malignant transformation and contributes… Expand
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Highly Cited
2005
Highly Cited
2005
The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53… Expand
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Highly Cited
2004
Highly Cited
2004
Vascular endothelial growth factor (VEGF) expression is elevated in ovarian and other cancer cells. However, the mechanism that… Expand
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Highly Cited
2003
Highly Cited
2003
The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is… Expand
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Highly Cited
2002
Highly Cited
2002
The function of cyclin G, a commonly induced p53 target, has remained elusive. We show that cyclin G forms a quaternary complex… Expand
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Highly Cited
2000
Highly Cited
2000
The p53 tumour-suppressor protein is negatively regulated by HDM2. Recent reports indicate that the leucine-rich nuclear-export… Expand
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Highly Cited
1999
Highly Cited
1999
The Hdm2 oncoprotein inhibits p53 functions by two means: (i) it blocks p53's transactivation activity and (ii) it targets p53… Expand
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Highly Cited
1998
Highly Cited
1998
The hdm2 gene is overexpressed in a variety of human tumors. Its gene product localizes predominantly to the nucleus, where it… Expand
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Highly Cited
1993
Highly Cited
1993
The MDM2 (murine double minute 2) gene has recently been shown to code for a cellular protein that can complex the p53 tumor… Expand
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