MDM2 wt Allele

Known as: hdm2, Mouse Double Minute 2 Homolog Gene, p53-Binding Protein Gene 
Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
024619982018

Papers overview

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2013
2013
The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells to inactive the p53 tumor suppressor pathway… (More)
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2010
2010
The E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the… (More)
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2008
2008
The Hdmx protein restricts p53 activity in vivo and is overexpressed in a significant fraction of human tumors that retain the… (More)
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Highly Cited
2006
Highly Cited
2006
Tumors that express wild-type P53 provide a target for therapies designed to reactivate P53 function. This is supported by the… (More)
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2006
2006
The p53 tumor suppressor plays a major role in maintaining genomic stability. Its activation and stabilization in response to… (More)
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2005
2005
The HDMX protein is closely related to HDM2 with which it shares different structural domains, particularly the p53 binding… (More)
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Highly Cited
2004
Highly Cited
2004
Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or… (More)
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Highly Cited
2003
Highly Cited
2003
The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING… (More)
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Highly Cited
2001
Highly Cited
2001
It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein… (More)
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2000
2000
The Mdm2 protein is a key regulator of p53 activity and stability. Upon binding, Mdm2 inhibits the transcription regulatory… (More)
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