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MDL 28170

Known as: MDL-28170, MDL28170 
National Institutes of Health

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Related topics

1 relation

Broader (1)

calpain inhibitor III

Papers overview

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2009
2009
Arrested growth of Trypanosoma cruzi by the calpain inhibitor MDL28170 and detection of calpain homologues in epimastigote forms
SUMMARY In this paper, we aimed to explore the effects of the calpain inhibitor III (MDL28170) and to detect calpain-like… 
Highly Cited
2008
Highly Cited
2008
Differential regulation of the NMDA receptor by acute and sub‐chronic phencyclidine administration in the developing rat
Neurodegeneration induced by the NMDA receptor antagonist, phencyclidine (PCP), has been used to model the pathogenesis of… 
2008
2008
Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury.
Although calpain (calcium-activated cysteine protease) inhibition represents a rational therapeutic target for spinal cord injury… 
2007
2007
Sustained Calpain Inhibition Improves Locomotor Function and Tissue Sparing Following Contusive Spinal Cord Injury
Following contusive spinal cord injury (SCI), calpain activity is dramatically increased and remains elevated for days to weeks… 
2007
2007
Cardiotrophin‐1 is an essential factor in the natural defense of the liver against apoptosis
We previously reported that exogenous cardiotrophin‐1 (CT‐1), a member of the IL‐6 family of cytokines, exerts hepatoprotective… 
2007
2007
Calcium Influx through L-type Channels Generates Protein Kinase M to Induce Burst Firing of Dopamine Cells in the Rat Ventral Tegmental Area*
Enhanced activity of the dopaminergic system originating in the ventral tegmental area is implicated in addictive and psychiatric… 
2005
2005
Calpain Inhibitor Inhibits p35-p25-Cdk5 Activation, Decreases Tau Hyperphosphorylation, and Improves Neurological Function after Spinal Cord Hemisection in Rats
Aberrant calpain activation is a key mediator of neuron death. We examined the cell-permeable calpain inhibitor MDL28170 in the… 
Highly Cited
2004
Highly Cited
2004
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures
2003
2003
Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection.
Calpains (calcium-activated cysteine proteases) are strongly implicated in the secondary damage that follows contusion injury to… 
2002
2002
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
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