MDL 28170

Known as: MDL-28170, MDL28170 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
051019912018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The calpain inhibitor MDL-28710 blocks the early local pro-inflammatory cytokine gene expression in mice after chronic… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2009
2009
Treatment of bovine pulmonary artery smooth muscle mitochondria with the calcium ionophore, A23187 (0.2 microM) stimulates mu… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2007
2007
It is known that calpain activation is involved in human traumatic brain injury (TBI) and that calpain inhibition can have… (More)
Is this relevant?
2006
2006
Several calpain inhibitors are under development and some are useful agents against important human pathogens. We therefore… (More)
Is this relevant?
2006
2006
The cytoskeleton controls the architecture and survival of the central nervous system neurons by maintaining the stability of… (More)
Is this relevant?
2005
2005
MDL 28170 is a CNS-penetrating calpain inhibitor, and we examined the effects of MDL 28170 on hypoxic-ischemic brain injury in… (More)
Is this relevant?
2003
2003
Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP) is a key component of Alzheimer's… (More)
Is this relevant?
2000
2000
Calpain, a Ca2+-dependent cysteine protease, has previously been implicated in apoptosis or programmed cell death (PCD) in immune… (More)
Is this relevant?
1998
1998
The newly-developed calpain inhibitor, MDL 28170 penetrates the blood-brain barrier and inhibits brain cysteine protease activity… (More)
Is this relevant?