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MDL 28170

Known as: MDL-28170, MDL28170 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Calpains are cytosolic calcium-activated cysteine proteases. Recently, they have been proposed to influence signal transduction… Expand
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Highly Cited
2012
Highly Cited
2012
ABSTRACT The ubiquitin-proteasome system (UPS) is involved in the replication of a broad range of viruses. Since replication of… Expand
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Review
2011
Review
2011
In vitro models of traumatic brain injury (TBI) are helping elucidate the pathobiological mechanisms responsible for dysfunction… Expand
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Highly Cited
2007
Highly Cited
2007
Tau hyperphosphorylation, amyloid plaques, and neuronal death are major neuropathological features of Alzheimer’s disease (AD… Expand
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Highly Cited
2004
Highly Cited
2004
Oxygen-glucose deprivation (OGD) induced neuron-specific cell death in organotypic hippocampal slice cultures. Neuronal death was… Expand
Highly Cited
2003
Highly Cited
2003
Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality… Expand
Highly Cited
2000
Highly Cited
2000
Recently, it was shown that conversion of cdk5 activator protein p35 to a C-terminal fragment p25 promotes a deregulation of cdk5… Expand
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Highly Cited
2000
Highly Cited
2000
Calpain, a Ca2+-dependent cysteine protease, has previously been implicated in apoptosis or programmed cell death (PCD) in immune… Expand
Highly Cited
1998
Highly Cited
1998
The newly-developed calpain inhibitor, MDL 28170 penetrates the blood-brain barrier and inhibits brain cysteine protease activity… Expand
Highly Cited
1997
Highly Cited
1997
The potential of protease inhibitors E-64, calpain inhibitor I (CPI-I) and MDL28170 to protect hippocampal neurons in an in vitro… Expand