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MDL 28170

Known as: MDL-28170, MDL28170 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

calpain inhibitor III

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides
Cyclin-dependent kinase 5 (Cdk5) is a serine-threonine kinase important for different cellular processes. Involved in tau protein… 
Highly Cited
2008
Highly Cited
2008
Differential regulation of the NMDA receptor by acute and sub‐chronic phencyclidine administration in the developing rat
Neurodegeneration induced by the NMDA receptor antagonist, phencyclidine (PCP), has been used to model the pathogenesis of… 
Highly Cited
2007
Highly Cited
2007
Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
It is known that calpain activation is involved in human traumatic brain injury (TBI) and that calpain inhibition can have… 
2007
2007
Sustained Calpain Inhibition Improves Locomotor Function and Tissue Sparing Following Contusive Spinal Cord Injury
Following contusive spinal cord injury (SCI), calpain activity is dramatically increased and remains elevated for days to weeks… 
Highly Cited
2004
Highly Cited
2004
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures
Highly Cited
2003
Highly Cited
2003
Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury.
Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality… 
2003
2003
Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection.
Calpains (calcium-activated cysteine proteases) are strongly implicated in the secondary damage that follows contusion injury to… 
Highly Cited
2000
Highly Cited
2000
Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.
Recently, it was shown that conversion of cdk5 activator protein p35 to a C-terminal fragment p25 promotes a deregulation of cdk5… 
Highly Cited
2000
Highly Cited
2000
Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells
Highly Cited
1997
Highly Cited
1997
Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity
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