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MDK protein, human

Known as: ARAP, neurite growth-promoting factor 2, human, Amphiregulin-Associated Protein 
Midkine (143 aa, ~16 kDa) is encoded by the human MDK gene. This protein plays a role in receptor signaling and the modulation of cell proliferation.
National Institutes of Health

Related topics

Related topics

11 relations
Binding ProteinsCell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor Gene

Broader (1)

Nerve Growth Factors

Papers overview

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Highly Cited
2004
Highly Cited
2004
A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin*
The Nogo66 receptor (NgR1) is a neuronal, leucinerich repeat (LRR) protein that binds three central nervous system (CNS) myelin… 
Highly Cited
2001
Highly Cited
2001
Haptotactic Migration Induced by Midkine
Midkine, a heparin-binding growth factor, plays a critical role in cell migration causing suppression of neointima formation in… 
Highly Cited
2001
Highly Cited
2001
Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma
Midkine (MK), a heparin binding growth factor, and cyclooxygenase-2 (COX-2), a key enzyme in the conversion of arachidonic acid… 
Highly Cited
2000
Highly Cited
2000
A heparin-binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG-M/versican.
Midkine is a heparin-binding growth factor with survival-promoting and migration-enhancing activities. In order to understand the… 
Highly Cited
2000
Highly Cited
2000
Immunohistochemical and In Situ Hybridization Analyses of Midkine Expression in Thyroid Papillary Carcinoma
Midkine (MK) is a novel heparin-binding growth factor whose gene has been identified in embryonal carcinoma cells in early stages… 
Highly Cited
1996
Highly Cited
1996
Midkine, a heparin-binding growth/differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro.
By means of a baculovirus expression system, a large amount of mouse midkine (MK) was produced. The protein was purified to… 
Highly Cited
1996
Highly Cited
1996
Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas.
Midkine (MK) is a growth factor that promotes neurite outgrowth and survival of neurons, and enhances the plasminogen activator… 
Highly Cited
1996
Highly Cited
1996
The expression of truncated MK in human tumors.
Midkine (MK) is a heparin binding growth/differentiation factor different from fibroblast growth factors (FGFs), and is largely… 
Highly Cited
1995
Highly Cited
1995
Midkine Enhances Fibrinolytic Activity of Bovine Endothelial Cells (*)
A hitherto unknown function of midkine (MK) was found in the regulation of fibrinolytic activity of vascular endothelial cells… 
Highly Cited
1987
Highly Cited
1987
A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons
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