Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 205,240,404 papers from all fields of science
Search
Sign In
Create Free Account
MDC 917
Known as:
MDC-917
, MDC917
National Institutes of Health
Create Alert
Alert
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Phospho‐ibuprofen (MDC‐917) incorporated in nanocarriers: anti‐cancer activity in vitro and in vivo
T. Nie
,
C. C. Wong
,
N. Alston
,
P. Aro
,
P. Constantinides
,
B. Rigas
British journal of pharmacology
2012
Corpus ID: 8393694
Phospho‐ibuprofen (P‐I; MDC‐917) inhibits the growth of colon cancer in mice. Here, we investigated the use of nanocarriers to…
Expand
2012
2012
Regioselective oxidation of phospho‐NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety
G. Xie
,
C. Wong
,
Ka-Wing Cheng
,
Liqun Huang
,
P. Constantinides
,
B. Rigas
British journal of pharmacology
2012
Corpus ID: 24036351
Phospho‐ibuprofen (MDC‐917) and phospho‐sulindac (OXT‐328) are highly effective in cancer and arthritis treatment in preclinical…
Expand
Highly Cited
2011
Highly Cited
2011
The novel phospho‐non‐steroidal anti‐inflammatory drugs, OXT‐328, MDC‐22 and MDC‐917, inhibit adjuvant‐induced arthritis in rats
L. Huang
,
G. Mackenzie
,
+5 authors
B. Rigas
British journal of pharmacology
2011
Corpus ID: 12622595
BACKGROUND AND PURPOSE The use of non‐steroidal anti‐inflammatory drugs (NSAIDs) in the treatment of rheumatoid arthritis (RA) is…
Expand
2011
2011
Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models
G. Xie
,
Yu Sun
,
+5 authors
B. Rigas
Journal of Pharmacology and Experimental…
2011
Corpus ID: 27243255
We have developed a novel chemical modification of conventional nonsteroidal anti-inflammatory drugs to reduce their toxicity and…
Expand
2011
2011
Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system
Yu Sun
,
Leahana M. Rowehl
,
+4 authors
B. Rigas
Breast Cancer Research
2011
Corpus ID: 17071437
IntroductionWe have recently synthesized phospho-ibuprofen (P-I; MDC-917), a safer derivative of ibuprofen, which has shown anti…
Expand
2011
2011
Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917): Preparation, Characterization, and In Vitro/In Vivo Evaluation
G. Mattheolabakis
,
T. Nie
,
P. Constantinides
,
B. Rigas
Pharmaceutical Research
2011
Corpus ID: 8929061
ABSTRACTPurposeTo incorporate phospho-ibuprofen (P-I), a lipophilic, water insoluble novel anti-cancer agent, into pegylated…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE