Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models

  title={Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models},
  author={Gang Xie and Yu Sun and Ting Nie and Gerardo G. Mackenzie and Liqun Huang and Levy Kopelovich and Despina Komninou and Basil Rigas},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={876 - 886}
  • G. Xie, Yu Sun, B. Rigas
  • Published 1 June 2011
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
We have developed a novel chemical modification of conventional nonsteroidal anti-inflammatory drugs to reduce their toxicity and enhance their efficacy. Phospho-ibuprofen [(PI) 2-(4-isobutyl-phenyl)-propionic acid-4-(diethoxy-phosphoryloxy)-butyl ester (MDC-917)], a novel derivative of ibuprofen, strongly inhibited the growth of human colon cancer cells in vitro and SW480 human colon cancer xenografts in nude mice. PI was metabolized minimally by cultured cells, but extensively by liver… 

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