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MB07133

Known as: Cytarabine Monophosphate Prodrug MB07133, MB-07133, MB 07133 
A prodrug of the monophosphate (MP) form of the antimetabolite cytarabine (araCMP), an analogue of cytidine with a modified sugar moiety (arabinose… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo
BackgroundTumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated… 
2017
2017
Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia
Drug resistance and human leukocyte antigen (HLA) matching limit conventional treatment of acute myeloid leukemia (AML). Although… 
2016
2016
Dual-drug loaded nanoformulation with a galactosamine homing moiety for liver-targeted anticancer therapy.
Drug resistance and unfavorable pharmacokinetics are the major obstacles for conventional anticancer drugs. A combination of… 
2007
2007
Novel Cyclic Phosphate Prodrug Approach for Cytochrome P450-activated Drugs Containing an Alcohol Functionality
PurposeA cyclic phosphate prodrug of a descriptive molecule containing an alcohol functionality was designed, synthesized and… 
2006
2006
A phase I/II study to assess the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) infusion of MB07133 in subjects with unresectable hepatocellular carcinoma (HCC).
2054 Background: MB07133 is a novel cytarabine (araC) prodrug that uses the HepDirect technology to target production of the… 
2002
2002
Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid artery.
Clinical success of percutaneous transluminal coronary angioplasty is limited by restenosis within months of the initial… 
Highly Cited
2000
Highly Cited
2000
Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice.
The bioreductive anticancer prodrug CI-1010 ((2R)-1-[(2-bromoethyl)amino]-3-(2-nitro-1H-imidazol-1-yl)-2-propanol hydrobromide… 
1998
1998
Comparative pharmacology of the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats, and humans.
Carzelesin is a novel cyclopropylpyrroloindole prodrug analogue that has recently been tested in Phase I clinical trials. To… 
1992
1992
A comparative study of the antitumor activities off 5‐deoxy‐5‐fluorouridine and its prodrug trimethoxy benzoyl‐5‐deoxy‐5‐fluorocytidine (Ro09–1390) on human digestive organ cancer xenograft lines…
5'-Deoxy-5-fluorouridine (5'-DFUR) is one of the oral fluoropyrimidines widely used in the treatment of gastric, colorectal and… 
1991
1991
In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate.
The prodrug p-[N,N-bis(2-chloroethyl)amino]phenyl phosphate (phenol mustard phosphate, POMP) was prepared from p-[N,N-bis(2… 
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