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MARK4 gene

Known as: MAP/Microtubule Affinity-Regulating Kinase 4 Gene, MARK4, Nbla00650 
This gene plays a role in protein phosphorylation.
National Institutes of Health

Related topics

Related topics

5 relations
Microtubule ProcessPhosphorylationSerine/Threonine PhosphorylationSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex… 
Review
2018
Review
2018
Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) has been suggested in several… 
Highly Cited
2018
Highly Cited
2018
Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression.
2014
2014
Mark4 promotes adipogenesis and triggers apoptosis in 3T3‐L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways
Microtubule affinity‐regulating kinase 4 (MARK4) deficiency has been reported to negatively regulate diet‐induced obesity and to… 
Highly Cited
2013
Highly Cited
2013
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the… 
Highly Cited
2012
Highly Cited
2012
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia in the elderly… 
Review
2009
Review
2009
The regulation and function of mammalian AMPK‐related kinases
AMP‐activated protein kinase (AMPK) is a key regulator of cellular and whole‐body energy homeostasis. Recently, 12 AMPK‐related… 
Highly Cited
2004
Highly Cited
2004
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes… 
Highly Cited
2003
Highly Cited
2003
The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines
Alterations of 19q13 are frequently observed in glial neoplasms, suggesting that this region harbors at least one gene involved… 
Highly Cited
2001
Highly Cited
2001
Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis.
Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the… 
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