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MAPKAP1 gene

Known as: MITOGEN-ACTIVATED PROTEIN KINASE-ASSOCIATED PROTEIN 1, MEKK2-INTERACTING PROTEIN 1, MGC2745 
This gene is involved in growth factor-mediated signaling.
National Institutes of Health

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MAPKAP1 wt Allele
Receptor SignalingSignal TransductionSignal Transduction InductionTarget of Rapamycin Complex 2 Subunit MAPKAP1

Papers overview

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2015
2015
Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ
Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450… 
2014
2014
Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses*
Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption… 
2014
2014
Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints
NMR structure determination of soluble proteins depends in large part on distance restraints derived from NOE. In this study, we… 
2014
2014
MAPKAP1 rs10118570 Polymorphism Is Associated with Anti-Infection and Anti-Hepatic Fibrogenesis in Schistosomiasis Japonica
Chronic infection with Schistosoma japonicum is an important cause of hepatic fibrosis (HF). Human 9q33.3 is one of the most… 
2012
2012
Integrity of mTORC2 is dependent on the rictor Gly-934 site
Growth factor signaling coupled to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway plays a crucial role in… 
1998
1998
Mutations in Chromatin Components Suppress a Defect of Gcn5 Protein in Saccharomyces cerevisiae
ABSTRACT The yeast GCN5 gene encodes the catalytic subunit of a nuclear histone acetyltransferase and is part of a high-molecular… 
1996
1996
Association of yeast SIN1 with the tetratrico peptide repeats of CDC23.
The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family… 
1996
1996
Association of yeast SAP1, a novel member of the ‘AAA’ ATPase family of proteins, with the chromatin protein SIN1
1995
1995
HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae
The Hpr1 protein has an unknown function, although it contains a region of homology to DNA topoisomerase I. We have found that… 
1980
1980
The antisuppressor strain sin1 of Schizosaccharomyces pombe lacks the modification isopentenyladenosine in transfer RNA.
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