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MAFA gene
Known as:
V-MAF AVIAN MUSCULOAPONEUROTIC FIBROSARCOMA ONCOGENE HOMOLOG A
, RIPE3b1
, hMafA
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This gene plays a role in the regulation of insulin gene expression.
National Institutes of Health
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Related topics
Related topics
4 relations
Homo sapiens
MAFA protein, human
Transcriptional Regulation
dna binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
ATF2 Interacts with β-Cell-enriched Transcription Factors, MafA, Pdx1, and Beta2, and Activates Insulin Gene Transcription*
Song-iee Han
,
K. Yasuda
,
K. Kataoka
The Journal of Biological Chemistry
2011
Corpus ID: 5814380
Pancreatic β-cell-restricted expression of insulin is established through several critical cis-regulatory elements located in the…
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2007
2007
Islet cell differentiation in liver by combinatorial expression of transcription factors neurogenin-3, BETA2, and RIPE3b1.
Y. Song
,
Eun-Jig Lee
,
P. Yashar
,
L. Pfaff
,
So-Youn Kim
,
J. Jameson
Biochemical and biophysical research…
2007
Corpus ID: 13294681
Highly Cited
2006
Highly Cited
2006
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
W. Nishimura
,
T. Kondo
,
+4 authors
Arun J Sharma
Developmental biology
2006
Corpus ID: 292540
Highly Cited
2002
Highly Cited
2002
Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
Martin Olbrot
,
Jonathan G. Rud
,
L. G. Moss
,
Arun J Sharma
Proceedings of the National Academy of Sciences…
2002
Corpus ID: 19632057
Of the three critical enhancer elements that mediate β-cell-specific and glucose-responsive expression of the insulin gene, only…
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2001
2001
Transcription Factors Recognizing Overlapping C1-A2 Binding Sites Positively Regulate Insulin Gene Expression*
R. Harrington
,
Arun J Sharma
The Journal of Biological Chemistry
2001
Corpus ID: 20126484
Transcription factors binding the insulin enhancer region, RIPE3b, mediate β-cell type-specific and glucose-responsive expression…
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2001
2001
The DNA Binding Activity of the RIPE3b1 Transcription Factor of Insulin Appears to Be Influenced by Tyrosine Phosphorylation*
T. Matsuoka
,
L. Zhao
,
R. Stein
The Journal of Biological Chemistry
2001
Corpus ID: 23654206
The RIPE3b1 DNA binding factor plays a critical role in pancreatic islet β cell-specific and glucose-regulated transcription of…
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2000
2000
The RIPE3b1 Activator of the Insulin Gene Is Composed of a Protein(s) of Approximately 43 kDa, Whose DNA Binding Activity Is Inhibited by Protein Phosphatase Treatment*
L. Zhao
,
M. A. Cissell
,
E. Henderson
,
R. Colbran
,
R. Stein
The Journal of Biological Chemistry
2000
Corpus ID: 13526443
Glucose-stimulated and pancreatic islet β cell-specific expression of the insulin gene is mediated in part by the C1 DNA-element…
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Highly Cited
1996
Highly Cited
1996
Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
V. Poitout
,
L. Olson
,
R. Robertson
The Journal of clinical investigation
1996
Corpus ID: 12131028
We have shown previously that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased…
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Highly Cited
1995
Highly Cited
1995
The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.
A. Sharma
,
L. Olson
,
R. Robertson
,
R. Stein
Molecular endocrinology
1995
Corpus ID: 5922146
The most important regulator of insulin gene expression in pancreatic beta- cells is glucose, which affects gene transcription…
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Highly Cited
1994
Highly Cited
1994
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.
A. Sharma
,
R. Stein
Molecular and cellular biology
1994
Corpus ID: 43518859
The insulin gene is expressed exclusively in pancreatic islet beta cells. The principal regulator of insulin gene transcription…
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