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MAFA gene

Known as: V-MAF AVIAN MUSCULOAPONEUROTIC FIBROSARCOMA ONCOGENE HOMOLOG A, RIPE3b1, hMafA 
This gene plays a role in the regulation of insulin gene expression.
National Institutes of Health

Related topics

Related topics

4 relations
Homo sapiensMAFA protein, humanTranscriptional Regulationdna binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription.
Pancreatic β-cell-restricted expression of insulin is established through several critical cis-regulatory elements located in the… Expand
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2007
2007
Islet cell differentiation in liver by combinatorial expression of transcription factors neurogenin-3, BETA2, and RIPE3b1.
Transcription factors, such as PDX-1, that normally mediate pancreatic development are capable of inducing hepatic progenitor… Expand
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Highly Cited
2006
Highly Cited
2006
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and… Expand
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Highly Cited
2002
Highly Cited
2002
Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
Of the three critical enhancer elements that mediate beta-cell-specific and glucose-responsive expression of the insulin gene… Expand
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2001
2001
Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression.
Transcription factors binding the insulin enhancer region, RIPE3b, mediate beta-cell type-specific and glucose-responsive… Expand
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2001
2001
The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.
The RIPE3b1 DNA binding factor plays a critical role in pancreatic islet beta cell-specific and glucose-regulated transcription… Expand
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2000
2000
The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.
Glucose-stimulated and pancreatic islet beta cell-specific expression of the insulin gene is mediated in part by the C1 DNA… Expand
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Highly Cited
1996
Highly Cited
1996
Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
We have shown previously that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased… Expand
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Highly Cited
1995
Highly Cited
1995
The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.
The most important regulator of insulin gene expression in pancreatic beta- cells is glucose, which affects gene transcription… Expand
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1994
1994
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.
The insulin gene is expressed exclusively in pancreatic islet beta cells. The principal regulator of insulin gene transcription… Expand
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