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MAD2L2 gene

Known as: MAD2B, MAD2 mitotic arrest deficient-like 2 (yeast), POLZ2 
This gene plays a role in both DNA translesion synthesis and the mitotic spindle assembly checkpoint.
National Institutes of Health

Related topics

Related topics

4 relations
Cell Cycle ControlDNA Synthesis RescueMAD2L2 protein, humanMitotic Spindle Checkpoints

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
PIPS one The Mitotic Arrest Deficient Protein MAD 2 B Interacts with the Clathrin Light Chain A during Mitosis
Background: Although the mitotic arrest deficient protein MAD2B (MAD2L2) is thought to inhibit the anaphase promoting complex… 
2016
2016
Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B
Background/Aims: Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the… 
2016
2016
MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis.
MAD2B, an anaphase-promoting complex/cyclosome (APC/C) inhibitor and a small subunit of DNA polymerase ζ, is indispensible for… 
2014
2014
Protection of neurons from high glucose-induced injury by deletion of MAD2B
Diabetic encephalopathy may lead to cognitive deficits in diabetic patients and diminish quality of life. It has been shown that… 
2012
2012
Analysis of the function of Mad2B in the mammalian cell cycle
Mad2B (also called Rev7 or Mad2L2) is a regulatory subunit of DNA polymerase ζ that is involved in translesion DNA synthesis (TLS… 
2010
2010
Crystal structure of human REV 7 in complex with a human REV 3 fragment and structural implication of the interaction between DNA polymerase ζ and REV 1
DNA polymerase ζ (Polζ) is an error-prone DNA polymerase involved in translesion DNA synthesis (TLS). Polζ consists of two… 
Highly Cited
2007
Highly Cited
2007
Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients.
2007
2007
Rev1 enhances CAG.CTG repeat stability in Saccharomyces cerevisiae.
2007
2007
Bacterial virulence: Shigella shoots, Shigella scores
10.1038/nrmicro1754 A new study published in Cell reports that Shigella flexneri influences intestinal epithelial-cell renewal… 
2006
2006
Inactivation of Human MAD 2 B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents
Rev7p has been suggested to play an important role in regulating DNA damage response in yeast, and recently, the human homologue… 
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