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Lysine-tRNA Ligase

Known as: Synthetase, Lysyl-tRNA, Lysyl-tRNA Synthetase, Ligase, Lysine-tRNA 
An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
National Institutes of Health

Related topics

Related topics

10 relations
In BloodKARS geneProcess of secretionantagonists & inhibitors
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Narrower (2)

KRS protein, humanlysX protein, Mycobacterium tuberculosis

Papers overview

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Highly Cited
2013
Highly Cited
2013
Structural switch of lysyl-tRNA synthetase between translation and transcription.
Lysyl-tRNA synthetase (LysRS), a component of the translation apparatus, is released from the cytoplasmic multi-tRNA synthetase… Expand
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Highly Cited
2012
Highly Cited
2012
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Summary With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites… Expand
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Highly Cited
2010
Highly Cited
2010
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P
Aminoacyl-tRNA synthetase (aaRS) paralogs with unknown functions exist in various species. We now report novel 'protein… Expand
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Review
2010
Review
2010
Formation of the tRNALys packaging complex in HIV‐1
Human immunodeficiency virus 1 (HIV‐1) uses a host cell tRNALys,3 molecule to prime reverse transcription of the viral RNA genome… Expand
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Highly Cited
2005
Highly Cited
2005
Nonconventional Involvement of LysRS in the Molecular Mechanism of USF2 Transcriptional Activity in FcεRI-Activated Mast Cells
ABSTRACT Reports of the biological multifunctional activity of various aminoacyl tRNA synthetases have recently accumulated in… Expand
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Highly Cited
2000
Highly Cited
2000
The Human Lysyl-tRNA Synthetase Gene Encodes Both the Cytoplasmic and Mitochondrial Enzymes by Means of an Unusual Alternative Splicing of the Primary Transcript*
Two cDNAs encoding human lysyl-tRNA synthetase have been identified. One encodes the cytoplasmic form of the enzyme identified… Expand
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Highly Cited
2000
Highly Cited
2000
Active site of lysyl-tRNA synthetase: structural studies of the adenylation reaction.
Aminoacyl-tRNA synthetases play a key role in protein biosynthesis by catalyzing the specific aminoacylation of tRNA. The energy… Expand
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Highly Cited
1997
Highly Cited
1997
Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi.
Lysyl-tRNAs are essential for protein biosynthesis by ribosomal mRNA translation in all organisms. They are synthesized by lysyl… Expand
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Highly Cited
1996
Highly Cited
1996
The crystal structures of T. thermophilus lysyl‐tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon…
The crystal structures of Thermus thermophilus lysyl‐tRNA synthetase, a class IIb aminoacyl‐tRNA synthetase, complexed with… Expand
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Highly Cited
1985
Highly Cited
1985
Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine.
Mutations in three Escherichia coli K-12 genes were isolated that reduce the efficiency of the lysine-inserting nonsense… Expand
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