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Lysine-tRNA Ligase
Known as:
Synthetase, Lysyl-tRNA
, Lysyl-tRNA Synthetase
, Ligase, Lysine-tRNA
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An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
National Institutes of Health
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Related topics
Related topics
10 relations
In Blood
KARS gene
Process of secretion
antagonists & inhibitors
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Narrower (2)
KRS protein, human
lysX protein, Mycobacterium tuberculosis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Structural switch of lysyl-tRNA synthetase between translation and transcription.
Yifat Ofir-Birin
,
P. Fang
,
+14 authors
M. Guo
Molecules and Cells
2013
Corpus ID: 11929216
Highly Cited
2013
Highly Cited
2013
Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89.
R. Santos-Cortez
,
Kwanghyuk Lee
,
+13 authors
S. Leal
American Journal of Human Genetics
2013
Corpus ID: 43019982
Highly Cited
2012
Highly Cited
2012
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
D. Hoepfner
,
C. McNamara
,
+22 authors
E. Winzeler
Cell Host and Microbe
2012
Corpus ID: 16742199
Highly Cited
2010
Highly Cited
2010
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P
T. Yanagisawa
,
T. Sumida
,
R. Ishii
,
C. Takemoto
,
S. Yokoyama
Nature Structural &Molecular Biology
2010
Corpus ID: 205523085
Aminoacyl-tRNA synthetase (aaRS) paralogs with unknown functions exist in various species. We now report novel 'protein…
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Review
2010
Review
2010
Formation of the tRNALys packaging complex in HIV‐1
L. Kleiman
,
Christopher P Jones
,
K. Musier-Forsyth
FEBS Letters
2010
Corpus ID: 207632831
Highly Cited
2000
Highly Cited
2000
The Human Lysyl-tRNA Synthetase Gene Encodes Both the Cytoplasmic and Mitochondrial Enzymes by Means of an Unusual Alternative Splicing of the Primary Transcript*
E. Tolkunova
,
Hyejeong Park
,
J. Xia
,
M. King
,
E. Davidson
Journal of Biological Chemistry
2000
Corpus ID: 25418996
Two cDNAs encoding human lysyl-tRNA synthetase have been identified. One encodes the cytoplasmic form of the enzyme identified…
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Highly Cited
1997
Highly Cited
1997
Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi.
M. Ibba
,
J. Bono
,
P. Rosa
,
D. Söll
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 11527357
Lysyl-tRNAs are essential for protein biosynthesis by ribosomal mRNA translation in all organisms. They are synthesized by lysyl…
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Highly Cited
1996
Highly Cited
1996
The crystal structures of T. thermophilus lysyl‐tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon…
S. Cusack
,
A. Yaremchuk
,
M. Tukalo
EMBO Journal
1996
Corpus ID: 12300699
The crystal structures of Thermus thermophilus lysyl‐tRNA synthetase, a class IIb aminoacyl‐tRNA synthetase, complexed with…
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Highly Cited
1990
Highly Cited
1990
Roles of the two lysyl-tRNA synthetases of Escherichia coli: analysis of nucleotide sequences and mutant behavior
R. L. Clark
,
F. Neidhardt
Journal of Bacteriology
1990
Corpus ID: 31106932
The complete nucleotide sequence of lysU, the gene for the heat-inducible lysyl-tRNA synthetase of Escherichia coli, was…
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Highly Cited
1985
Highly Cited
1985
Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine
M. Sullivan
,
J. Cannon
,
F. Webb
,
R. Bock
Journal of Bacteriology
1985
Corpus ID: 20451545
Mutations in three Escherichia coli K-12 genes were isolated that reduce the efficiency of the lysine-inserting nonsense…
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