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Lysine-tRNA Ligase

Known as: Synthetase, Lysyl-tRNA, Lysyl-tRNA Synthetase, Ligase, Lysine-tRNA 
An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
National Institutes of Health

Related topics

Related topics

10 relations
In BloodKARS geneProcess of secretionantagonists & inhibitors
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Narrower (2)

KRS protein, humanlysX protein, Mycobacterium tuberculosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Structural switch of lysyl-tRNA synthetase between translation and transcription.
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Highly Cited
2013
Highly Cited
2013
Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89.
Highly Cited
2012
Highly Cited
2012
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Summary With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites… 
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Highly Cited
2010
Highly Cited
2010
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P
Aminoacyl-tRNA synthetase (aaRS) paralogs with unknown functions exist in various species. We now report novel 'protein… 
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Review
2010
Review
2010
Formation of the tRNALys packaging complex in HIV‐1
Highly Cited
2000
Highly Cited
2000
The Human Lysyl-tRNA Synthetase Gene Encodes Both the Cytoplasmic and Mitochondrial Enzymes by Means of an Unusual Alternative Splicing of the Primary Transcript*
Two cDNAs encoding human lysyl-tRNA synthetase have been identified. One encodes the cytoplasmic form of the enzyme identified… 
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Highly Cited
1997
Highly Cited
1997
Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi.
Lysyl-tRNAs are essential for protein biosynthesis by ribosomal mRNA translation in all organisms. They are synthesized by lysyl… 
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Highly Cited
1996
Highly Cited
1996
The crystal structures of T. thermophilus lysyl‐tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon…
The crystal structures of Thermus thermophilus lysyl‐tRNA synthetase, a class IIb aminoacyl‐tRNA synthetase, complexed with… 
Highly Cited
1990
Highly Cited
1990
Roles of the two lysyl-tRNA synthetases of Escherichia coli: analysis of nucleotide sequences and mutant behavior
The complete nucleotide sequence of lysU, the gene for the heat-inducible lysyl-tRNA synthetase of Escherichia coli, was… 
Highly Cited
1985
Highly Cited
1985
Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine
Mutations in three Escherichia coli K-12 genes were isolated that reduce the efficiency of the lysine-inserting nonsense… 
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