Lysine-tRNA Ligase

Known as: Synthetase, Lysyl-tRNA, Lysyl-tRNA Synthetase, Ligase, Lysine-tRNA 
An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
National Institutes of Health

Related topics

Related topics

10 relations
In BloodKARS geneProcess of secretionantagonists & inhibitors
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Narrower (2)

KRS protein, humanlysX protein, Mycobacterium tuberculosis

Papers overview

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2013
2013
Structural switch of lysyl-tRNA synthetase between translation and transcription.
Lysyl-tRNA synthetase (LysRS), a component of the translation apparatus, is released from the cytoplasmic multi-tRNA synthetase… (More)
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2013
2013
Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89.
Previously, DFNB89, a locus associated with autosomal-recessive nonsyndromic hearing impairment (ARNSHI), was mapped to… (More)
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Highly Cited
2012
Highly Cited
2012
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and… (More)
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Highly Cited
2010
Highly Cited
2010
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P
Aminoacyl-tRNA synthetase (aaRS) paralogs with unknown functions exist in various species. We now report novel 'protein… (More)
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Review
2010
Review
2010
Formation of the tRNALys packaging complex in HIV-1.
Human immunodeficiency virus 1 (HIV-1) uses a host cell tRNA(Lys,3) molecule to prime reverse transcription of the viral RNA… (More)
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2004
2004
Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants.
In vitro transcription has proven to be a successful tool for preparation of functional RNAs, especially in the tRNA field, in… (More)
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Highly Cited
2000
Highly Cited
2000
The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript.
Two cDNAs encoding human lysyl-tRNA synthetase have been identified. One encodes the cytoplasmic form of the enzyme identified… (More)
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1997
1997
Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi.
Lysyl-tRNAs are essential for protein biosynthesis by ribosomal mRNA translation in all organisms. They are synthesized by lysyl… (More)
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1996
1996
The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon…
The crystal structures of Thermus thermophilus lysyl-tRNA synthetase, a class IIb aminoacyl-tRNA synthetase, complexed with… (More)
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1985
1985
Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine.
Mutations in three Escherichia coli K-12 genes were isolated that reduce the efficiency of the lysine-inserting nonsense… (More)
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