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Lysine-tRNA Ligase

Known as: Synthetase, Lysyl-tRNA, Lysyl-tRNA Synthetase, Ligase, Lysine-tRNA 
An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
National Institutes of Health

Related topics

Related topics

10 relations
In BloodKARS geneProcess of secretionantagonists & inhibitors

Narrower (2)

KRS protein, humanlysX protein, Mycobacterium tuberculosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent.
The antimalarial agent cladosporin is a nanomolar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits… 
Highly Cited
2007
Highly Cited
2007
Lysyl-tRNA Synthetase-generated Lysyl-Adenylate Is a Substrate for Histidine Triad Nucleotide Binding Proteins*
Histidine triad nucleotide binding proteins (Hints) are the most ancient members of the histidine triad protein superfamily of… 
2007
2007
Engineered Monomeric Human Histidine Triad Nucleotide-binding Protein 1 Hydrolyzes Fluorogenic Acyl-adenylate and Lysyl-tRNA Synthetase-generated Lysyl-adenylate*
Hint1 is a homodimeric protein and member of the ubiquitous HIT superfamily. Hint1 catalyzes the hydrolysis of purine… 
2007
2007
Critical Role of Helix 4 of HIV-1 Capsid C-terminal Domain in Interactions with Human Lysyl-tRNA Synthetase*
Human tRNALys3 is used as the primer for human immunodeficiency virus type 1 (HIV-1) reverse transcription. HIV-1 Gag and GagPol… 
Highly Cited
2004
Highly Cited
2004
Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants.
In vitro transcription has proven to be a successful tool for preparation of functional RNAs, especially in the tRNA field, in… 
1994
1994
Autoantibodies to a transfer RNA-associated protein in a murine model of chronic graft versus host disease.
We established chronic graft vs host disease (GVHD) in (C57BL/10 x DBA/2)F1 mice with an injection of lymphoid cells from the… 
Highly Cited
1992
Highly Cited
1992
Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms
Highly Cited
1990
Highly Cited
1990
Roles of the two lysyl-tRNA synthetases of Escherichia coli: analysis of nucleotide sequences and mutant behavior
The complete nucleotide sequence of lysU, the gene for the heat-inducible lysyl-tRNA synthetase of Escherichia coli, was… 
1985
1985
Synthesis of diadenosine 5',5''' -P1,P4-tetraphosphate by lysyl-tRNA synthetase and a multienzyme complex of aminoacyl-tRNA synthetases from rat liver.
Highly Cited
1983
Highly Cited
1983
Gene for Heat-Inducible Lysyl-tRNA Synthetase (lysU) Maps near cadA in Escherichia coli
A hybrid ColE1 plasmid from the Clarke-Carbon colony bank with a 7-kilobase insertion was found to encode the inducible lysyl… 
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