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Lysine-Specific Demethylase 5C

Known as: KDM5C, SMCX protein, human, Protein Xe169 
Lysine-specific demethylase 5C (1560 aa, ~176 kDa) is encoded by the human KDM5C gene. This protein is involved in both chromatin modification and… 
National Institutes of Health

Related topics

Related topics

16 relations
ARID DomainCell NucleusChromatin Remodeling FactorEnzyme Gene

Broader (1)

Histone Demethylases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos.
Insufficient epigenetic reprogramming is incompatible with normal development of embryos produced by somatic cell nuclear… 
2018
2018
Genomic alterations to refine prognostication of patients with metastatic renal cell carcinoma.
626Background: The IMDC risk score is a valid and simple tool to prognosticate patients (pts) with metastatic renal cell… 
2018
2018
A central anti-oncogenic pathway in ccRCC
2017
2017
Use of liquid biopsy for detection of renal cell carcinoma.
521Background: Circulating tumor DNA (ctDNA) displays characteristics of an ideal serum biomarker. We sought to develop whole… 
2016
2016
Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression
Gastric cancer is a malignancy with high incidence and the second leading cause of cancer death worldwide. Development of… 
2016
2016
Abstract 1240: Targeting epigenetic regulation in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell cancer, is highly resistant to traditional… 
2016
2016
Abstract 3254: Discovery of histone demethylase KDM5C inactivation as a novel mechanism for tumors resistant to VEGF RTKi via genome-wide in-vivo RNAi
Acquired tumor resistance to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (RTKi) constitutes a… 
2016
2016
Analysis of mutational status in recurrently mutated genes in clear cell renal cell carcinoma and overall survival in patients with metastatic disease at time of nephrectomy.
520 Background: Using the genetic profile of a tumor, clinicians may be able to give insight in to the aggressiveness or… 
2015
2015
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression
Hepatocellular carcinoma (HCC) is the most common type of tumor and is associated with high morbidity and mortality rates… 
2013
2013
Association of mutations in chromatin modifiers with poor survival in clear cell renal cell carcinoma: Analysis of the Cancer Genome Atlas Project.
360 Background: We have previously shown that mutations in the epigenetic modifiers PBRM1, BAP1, SETD2 and KDM5C are associated… 
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