Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression

@inproceedings{Xu2017EnhancementOP,
  title={Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression},
  author={Liming Xu and Wei Wu and Guilian Cheng and Mingjie Qian and Kewei Hu and Guojian Yin and Shaofeng Wang},
  booktitle={Technology in cancer research & treatment},
  year={2017}
}
Gastric cancer is a malignancy with high incidence and the second leading cause of cancer death worldwide. Development of efficient therapies against gastric cancer is urgent. Until now, the mechanisms of gastric cancer genesis remain elusive. The KDM5C is a histone demethylase that promotes cancer cell growth and is enriched in drug-resistant cancer cells. But the pathogenic breadth and mechanistic aspects of this effect relative to gastric cancer have not been defined. In present study, we… CONTINUE READING