Ly-2127399

Known as: LY2127399, LY3022859 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

tabalumab

Papers overview

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2017
2017
A phase 1 study of anti-TGFβ receptor type-II monoclonal antibody LY3022859 in patients with advanced solid tumors
LY3022859 is an anti-TGFβRII IgG1 monoclonal antibody that inhibits receptor-mediated signaling activation. The primary objective… (More)
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2016
2016
Dose‐escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
B-cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an… (More)
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Review
2015
Review
2015
Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises several clinical entities with diverse clinical… (More)
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Review
2012
Review
2012
Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development?
For the first time in more than 50 years, the US Food and Drug Administration has approved a drug specifically for the treatment… (More)
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2011
2011
Phase I study of LY2127399, a human anti-BAFF antibody, and bortezomib in patients with previously treated multiple myeloma.
8012 Background: LY2127399 (LY) is a human mAb that neutralizes membrane-bound and soluble B cell activating factor (BAFF). LY… (More)
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Review
2011
Review
2011
Targeting Bone as a Therapy for Myeloma
Myeloma bone disease (BD) not only impairs quality of life, but is also associated with impaired survival. Studies of the biology… (More)
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Review
2010
Review
2010
Treating multiple sclerosis with monoclonal antibodies: a 2010 update.
Treating multiple sclerosis (MS) with monoclonal antibodies (mAbs) has been marked by both progress and setbacks in the past 2… (More)
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Review
2010
Review
2010
Treating multiple sclerosis with monoclonal antibodies: a 2013 update.
The third part of this in-depth review series on the treatment of multiple sclerosis (MS) with monoclonal antibodies covers the… (More)
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