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Lucanthone

Known as: 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, Lucantona, 1-diethylaminoethylethylamino-4-methyl-thioxanthenone 
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1… 
National Institutes of Health

Related topics

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18 relations

Narrower (7)

4-desmethyllucanthone7-methylthioxanthone-2-carboxylic acidIA 3Lucanthone Hydrochloride
In BloodNCIt Antineoplastic Agent TerminologyPoisoning by anthelminthicsagonists

Broader (1)

Schistosomicides

Papers overview

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1980
1980
In vitro information system for collection and analysis of experimental data.
The In Vitro information System (IVIS) provides for the collection, maintenance, analysis and reporting of mutagenesis data for… 
1980
1980
Effect of dihydroxyanthraquinone and radiation on G2 progression.
The effect of dihydroxyanthraquinone (DHAQ), a potential anticancer chemotherapeutic agent, on the progression of Chinese hamster… 
1979
1979
Effect of lucanthone (miracil D) on transcription of ribosomal RNA genes from Tetrahymena in vivo and in vitro.
Addition of lucanthone (1-5 mug/ml) to cultures of Tetrahymena results in a preferential inhibition of the synthesis of ribosomal… 
1979
1979
The effect of lucanthone on the radiation response of intestinal stem cells in Chinese hamsters.
Crypt microcolony assay was used to determine the effect of lucanthone on the radiation response of intestinal stem cells in… 
1977
1977
Effects of lucanthone on the sedimentation properties of DNA from HeLa cells.
Exposure of HeLa cells to lucanthone (3 microgram/ml) caused dissociation of a fast-sedimenting duplex DNA complex, as judged by… 
1977
1977
Radiation damage in mouse embryos exposed to 1 rad X-rays or negative pions
Pregnant mice of two different strains (F/A and NMRI) were exposed to 1 rad of whole-body pion- or X-irradiation at day 8 of… 
1973
1973
Acceleration of the growth of populations and of the multiplication of tetrathyridia of Mersocestoides corti Hoeppli, 1925 (Cestoda: Cyclophyllidea) by some cytostatic agents.
Experiments with tetrathyridia of Mesocestoides corti implanted intraperitoneally into LDF1, SEC, and SWR mice showed that a… 
1972
1972
Combined lethal effects of lucanthone (miracil D) and total-body irradiation in mice.
Sublethal doses of lucanthone (Miracil D) induced substantial mortality when administered to sublethally irradiated mice… 
1971
1971
Thioxanthones. II. Studies on the hydrogen-bonding capacity of lucanthone.
Lucanthone (1-diethylaminoethylamino-4-methylthioxanthone) is a bacteriostatic and carcinostatic agent, and combines readily with… 
1968
1968
Preliminary clinical trials with hycanthone, a new antischistosomal agent.
Summary From Miracil D® (lucanthone), a hydroxymethyl derivative (hycanthone), can be obtained through the biological activity of…