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Lucanthone

Known as: 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, Lucantona, 1-diethylaminoethylethylamino-4-methyl-thioxanthenone 
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (7)

4-desmethyllucanthone7-methylthioxanthone-2-carboxylic acidIA 3Lucanthone Hydrochloride
In BloodNCIt Antineoplastic Agent TerminologyPoisoning by anthelminthicsagonists

Broader (1)

Schistosomicides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1983
1983
Aza analogues of lucanthone: synthesis and antitumor and bactericidal properties.
Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs. None of the compounds was found to… 
1982
1982
Nitro and amino derivatives of lucanthone as antitumor agents.
A group of nitro and amino derivatives of lucanthone was prepared and tested for antitumor activity. Reaction of 1-chloro-4… 
1980
1980
In vitro information system for collection and analysis of experimental data.
The In Vitro information System (IVIS) provides for the collection, maintenance, analysis and reporting of mutagenesis data for… 
1980
1980
Effect of dihydroxyanthraquinone and radiation on G2 progression.
The effect of dihydroxyanthraquinone (DHAQ), a potential anticancer chemotherapeutic agent, on the progression of Chinese hamster… 
1977
1977
Effects of lucanthone on the sedimentation properties of DNA from HeLa cells.
Exposure of HeLa cells to lucanthone (3 microgram/ml) caused dissociation of a fast-sedimenting duplex DNA complex, as judged by… 
1973
1973
Acceleration of the growth of populations and of the multiplication of tetrathyridia of Mersocestoides corti Hoeppli, 1925 (Cestoda: Cyclophyllidea) by some cytostatic agents.
Experiments with tetrathyridia of Mesocestoides corti implanted intraperitoneally into LDF1, SEC, and SWR mice showed that a… 
1972
1972
Combined lethal effects of lucanthone (miracil D) and total-body irradiation in mice.
Sublethal doses of lucanthone (Miracil D) induced substantial mortality when administered to sublethally irradiated mice… 
1971
1971
Thioxanthones. II. Studies on the hydrogen-bonding capacity of lucanthone.
Lucanthone (1-diethylaminoethylamino-4-methylthioxanthone) is a bacteriostatic and carcinostatic agent, and combines readily with… 
Highly Cited
1970
Highly Cited
1970
Enhancement of x-ray damage in HeLa cells by exposure to lucanthone (Miracil D) following radiation.
Summary The colony-forming ability of HeLa cells that survived an initial dose of X-irradiation proved abnormally sensitive to… 
1968
1968
Preliminary clinical trials with hycanthone, a new antischistosomal agent.
Summary From Miracil D® (lucanthone), a hydroxymethyl derivative (hycanthone), can be obtained through the biological activity of… 
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