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Lucanthone

Known as: 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, Lucantona, 1-diethylaminoethylethylamino-4-methyl-thioxanthenone 
An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (7)

4-desmethyllucanthone7-methylthioxanthone-2-carboxylic acidIA 3Lucanthone Hydrochloride
In BloodNCIt Antineoplastic Agent TerminologyPoisoning by anthelminthicsagonists

Broader (1)

Schistosomicides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules.
1982
1982
Development and cross-resistance characteristics of a subline of P388 leukemia resistant to 4'-(9-acridinylamino)-methanesulfon-m-anisidide.
1980
1980
Schistosoma mansoni: drug induced changes in the cell population of the vitelline gland.
Highly Cited
1980
Highly Cited
1980
Factors affecting the heat-induced increase in protein content of chromatin.
When HeLa cells are heated (40 to 48/sup 0/C), a time- and temperature-dependent increase in the chromatin protein content is… 
1975
1975
Effects of low concentrations of actinomycin D on the initiation of DNA synthesis in rapidly proliferating and stimulated cell cultures.
Highly Cited
1973
Highly Cited
1973
Studies with the schistosomicide oxamniquine (UK-4271). I. Activity in rodents and in vitro.
1972
1972
Actinomycin D induction of acid phosphatase in synchronized L5178Y mouse leukemia cells.
1972
1972
Resistance of bacteriophage PBS2 infection to rifampicin, an inhibitor of Bacillus subtilis RNA synthesis.
Highly Cited
1970
Highly Cited
1970
Enhancement of x-ray damage in HeLa cells by exposure to lucanthone (Miracil D) following radiation.
Summary The colony-forming ability of HeLa cells that survived an initial dose of X-irradiation proved abnormally sensitive to… 
1969
1969
Reversible inhibition of ribosomal RNA synthesis in HeLa by lucanthone (Miracil D) with continued synthesis of DNA‐like RNA
Ribosomal RNA synthesis was selectively inhibited in HeLa cells by lucanthone, a clinically useful schistosomicide which shares… 
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