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Lower Limit of Quantitation
Known as:
LLOQ
, Lower Limit Value
The lowest value in a possible range of values for a particular assessment.
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Standardized LC–MS/MS based steroid hormone profile-analysis
T. Koal
,
Diane Schmiederer
,
H. Pham-Tuan
,
C. Roehring
,
M. Rauh
The Journal of Steroid Biochemistry and Molecular…
2012
Corpus ID: 21520920
In order to overcome many limitations of immunoassays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS…
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Highly Cited
2010
Highly Cited
2010
A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate.
Christian Spangler
,
A. Böhm
,
U. Jenal
,
R. Seifert
,
V. Kaever
Journal of microbiological methods
2010
Corpus ID: 39521694
Cyclic di-guanosine monophosphate (c-di-GMP) represents an important ubiquitous second messenger in bacteria. It controls the…
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Highly Cited
2008
Highly Cited
2008
Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry.
Olivier Heudi
,
Samuel Barteau
,
+5 authors
O. Kretz
Analytical chemistry
2008
Corpus ID: 37331182
Although LC-MS methods are increasingly used for the absolute quantification of proteins, the lack of appropriate internal…
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Highly Cited
2008
Highly Cited
2008
Automated GC-MS analysis of free amino acids in biological fluids.
H. Kaspar
,
K. Dettmer
,
W. Gronwald
,
P. Oefner
Journal of chromatography. B, Analytical…
2008
Corpus ID: 25395243
A gas chromatography-mass spectrometry (GC-MS) method was developed for the quantitative analysis of free amino acids as their…
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Highly Cited
2008
Highly Cited
2008
Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients
T. Dorlo
,
P. V. van Thiel
,
+4 authors
P. D. de Vries
Antimicrobial Agents and Chemotherapy
2008
Corpus ID: 6160342
ABSTRACT The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and…
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Highly Cited
2008
Highly Cited
2008
Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate…
N. Lindegårdh
,
A. Annerberg
,
N. White
,
N. Day
Journal of chromatography. B, Analytical…
2008
Corpus ID: 26057262
A bioanalytical method for the analysis of piperaquine in human plasma using off-line solid-phase extraction and liquid…
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Highly Cited
2005
Highly Cited
2005
Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry.
T. Koal
,
H. Burhenne
,
R. Roemling
,
M. Svoboda
,
K. Resch
,
Volkhard Kaever
Rapid communications in mass spectrometry : RCM
2005
Corpus ID: 37847273
For the first time approved antiretroviral drugs, i.e. protease inhibitors (PI) and non-nucleoside reverse transcriptase…
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Highly Cited
2004
Highly Cited
2004
Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules
Binodh Desilva
,
W. Smith
,
+7 authors
A. Celniker
Pharmaceutical Research
2004
Corpus ID: 971738
AbstractPurpose.With this publication a subcommittee of the AAPS Ligand Binding Assay Bioanalytical Focus Group (LBABFG) makes…
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Highly Cited
2003
Highly Cited
2003
Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: practical approaches to their elimination.
J. Schuhmacher
,
D. Zimmer
,
Frank Tesche
,
V. Pickard
Rapid communications in mass spectrometry : RCM
2003
Corpus ID: 44203519
Some cases of occurrence of matrix effects (mostly ion suppression) in protein-precipitated plasma samples, and their influence…
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Highly Cited
2003
Highly Cited
2003
Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species.
R. Geary
,
R. Yu
,
+7 authors
A. Levin
Drug metabolism and disposition: the biological…
2003
Corpus ID: 11709308
The pharmacokinetics of a 2'-O-(2-methoxyethyl)-ribose modified phosphorothioate oligonucleotide, ISIS 104838 (human tumor…
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