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Lower Limit of Quantitation

Known as: LLOQ, Lower Limit Value 
The lowest value in a possible range of values for a particular assessment.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Determination of monoamine and amino acid neurotransmitters and their metabolites in rat brain samples by UFLC-MS/MS for the study of the sedative-hypnotic effects observed during treatment with S…
Highly Cited
2013
Highly Cited
2013
Rapid screening of drugs of abuse in human urine by high-performance liquid chromatography coupled with high resolution and high mass accuracy hybrid linear ion trap-Orbitrap mass spectrometry.
Highly Cited
2008
Highly Cited
2008
Standardized, mathematical model-based and validated in vitro analysis of anthrax lethal toxin neutralization.
Highly Cited
2006
Highly Cited
2006
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Gemcitabine triphosphate (dFdCTP) is a highly active metabolite of gemcitabine. It is formed intra-cellularly via the… 
2006
2006
A monolithic-phase based on-line extraction approach for determination of pharmaceutical components in human plasma by HPLC-MS/MS and a comparison with liquid-liquid extraction.
2005
2005
Quantification of docetaxel and its main metabolites in human plasma by liquid chromatography/tandem mass spectrometry.
Docetaxel is an antineoplastic agent widely used in therapeutics. The objective of this study was to develop and validate a… 
Highly Cited
2005
Highly Cited
2005
On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass…
A sensitive and reproducible method for the determination of morphine and the metabolites morphine-3-glucuronide (M3G) and… 
Highly Cited
2002
Highly Cited
2002
Generic serial and parallel on-line direct-injection using turbulent flow liquid chromatography/tandem mass spectrometry.
The development of turbulent flow chromatography (TFC) has enabled considerable growth in the utility of on-line direct-injection… 
2000
2000
Pharmacokinetics, Pharmacodynamics, and Safety of Microencapsulated Octreotide Acetate in Healthy Subjects
The pharmacokinetics, pharmacodynamics, and safety of the marketed formulation of microencapsulated octreotide acetate were… 
Highly Cited
2000
Highly Cited
2000
Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma.
Methylphenidate (MPH; Ritalin: methyl-alpha-phenyl-2-piperidinacetate hydrochloride) is utilized for the treatment of attention… 
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