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Lower Limit of Quantitation

Known as: LLOQ, Lower Limit Value 
The lowest value in a possible range of values for a particular assessment.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Standardized LC–MS/MS based steroid hormone profile-analysis
In order to overcome many limitations of immunoassays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS… Expand
Highly Cited
2010
Highly Cited
2010
A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate.
Cyclic di-guanosine monophosphate (c-di-GMP) represents an important ubiquitous second messenger in bacteria. It controls the… Expand
Highly Cited
2008
Highly Cited
2008
Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry.
Although LC-MS methods are increasingly used for the absolute quantification of proteins, the lack of appropriate internal… Expand
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Highly Cited
2008
Highly Cited
2008
Automated GC-MS analysis of free amino acids in biological fluids.
A gas chromatography-mass spectrometry (GC-MS) method was developed for the quantitative analysis of free amino acids as their… Expand
Highly Cited
2008
Highly Cited
2008
Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients
ABSTRACT The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and… Expand
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Highly Cited
2008
Highly Cited
2008
Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate…
A bioanalytical method for the analysis of piperaquine in human plasma using off-line solid-phase extraction and liquid… Expand
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Highly Cited
2005
Highly Cited
2005
Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry.
For the first time approved antiretroviral drugs, i.e. protease inhibitors (PI) and non-nucleoside reverse transcriptase… Expand
Highly Cited
2004
Highly Cited
2004
Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules
AbstractPurpose.With this publication a subcommittee of the AAPS Ligand Binding Assay Bioanalytical Focus Group (LBABFG) makes… Expand
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Highly Cited
2003
Highly Cited
2003
Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: practical approaches to their elimination.
Some cases of occurrence of matrix effects (mostly ion suppression) in protein-precipitated plasma samples, and their influence… Expand
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Highly Cited
2003
Highly Cited
2003
Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species.
  • R. Geary, R. Yu, +7 authors A. Levin
  • Drug metabolism and disposition: the biological…
  • 2003
    • Corpus ID: 11709308
The pharmacokinetics of a 2'-O-(2-methoxyethyl)-ribose modified phosphorothioate oligonucleotide, ISIS 104838 (human tumor… Expand
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