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Loperamide

Known as: Loperamide [Chemical/Ingredient], Loperamid, 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl- 
A synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the… 
National Institutes of Health

Related topics

Related topics

28 relations

Broader (1)

Antidiarrheals
Colonic Diseases, FunctionalConstipationDiarrheaDrug Allergy

Narrower (5)

ImodiumLoperamide / SimethiconeN-hydroxymethyl-N-desmethylloperamideT263 compound

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Nano-electromembrane extraction.
Highly Cited
2012
Highly Cited
2012
Exhaustive electromembrane extraction of some basic drugs from human plasma followed by liquid chromatography-mass spectrometry.
2010
2010
Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications.
2007
2007
Development of in situ ion selective sensors for dissolution.
2002
2002
Effects of full-thickness burns on nociceptor sensitization in anesthetized rats.
Highly Cited
1997
Highly Cited
1997
Phase II trial of irinotecan in patients with metastatic colorectal carcinoma.
PURPOSE To evaluate the objective tumor response rate and toxicities of patients with metastatic colorectal carcinoma treated… 
Highly Cited
1995
Highly Cited
1995
Risk of bowel dysfunction with diarrhea after continent urinary diversion with ileal and ileocecal segments.
1982
1982
Opioid peptides inhibit intestinal transit in the rat by a central mechanism.
Highly Cited
1982
Highly Cited
1982
Antidiarrhoeal activity of loperamide: studies of its influence on ion transport across rabbit ileal mucosa in vitro.
Loperamide is a well-established antidiarrhoeal agent with effects on gastrointestinal motility. We have now shown that the drug… 
Highly Cited
1979
Highly Cited
1979
Toxic megacolon associated with loperamide therapy.
  • J. W. Brown
  • Journal of the American Medical Association (JAMA…
  • 1979
  • Corpus ID: 45911617
TOXIC megacolon is a well-known serious complication of fulminant ulcerative colitis and has been reported to occur in… 
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