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Loperamide

Known as: Loperamide [Chemical/Ingredient], Loperamid, 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl- 
A synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the… 
National Institutes of Health

Related topics

Related topics

28 relations

Broader (1)

Antidiarrheals
Colonic Diseases, FunctionalConstipationDiarrheaDrug Allergy

Narrower (5)

ImodiumLoperamide / SimethiconeN-hydroxymethyl-N-desmethylloperamideT263 compound

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Interactions Between Herbal Medicines and Prescribed Drugs
The concomitant use of herbal medicines and pharmacotherapy is wide spread. We have reviewed the literature to determine the… 
Highly Cited
2010
Highly Cited
2010
The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats
BackgroundConstipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal… 
Review
2008
Review
2008
A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs
Highly Cited
2008
Highly Cited
2008
Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial.
Review
2007
Review
2007
Journal of Occupational Medicine and Toxicology Nanotechnology-based Drug Delivery Systems
Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in… 
Review
2006
Review
2006
Systematic review: microscopic colitis
Collagenous and lymphocytic colitis are fairly common causes of chronic non‐bloody diarrhoea, especially in elderly female. 
Highly Cited
2005
Highly Cited
2005
Hydrolysis of Capecitabine to 5′-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide
Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast and colorectal cancers. A three… 
Review
2002
Review
2002
Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.
The camptothecins are a maturing class of anticancer agents. In this article, we review the pharmacology and antitumor activity… 
Highly Cited
2000
Highly Cited
2000
Increased drug delivery to the brain by P‐glycoprotein inhibition
Although the antidiarrheal loperamide is a potent opiate, it does not produce opioid central nervous system effects at usual… 
Highly Cited
1994
Highly Cited
1994
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea.
BACKGROUND Diarrhea is a serious side effect that may prevent the administration of high doses of the antitumor drug Irinotecan… 
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