Loperamide

Known as: Loperamide [Chemical/Ingredient], Loperamid, 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl- 
A synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2018
05019722018

Papers overview

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Highly Cited
2007
Highly Cited
2007
The identification of protein function based on biological information is an area of intense research. Here we consider a… (More)
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Highly Cited
2007
Highly Cited
2007
Polymeric nanoparticles (Np) represent one of the most innovative non-invasive approaches for the drug delivery to the central… (More)
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Highly Cited
2002
Highly Cited
2002
Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous… (More)
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Highly Cited
1997
Highly Cited
1997
Purpose. The possibility of using polysorbate 80-coated nanoparticles for the delivery of the water insoluble opioid agonist… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Stool form scales are a simple method of assessing intestinal transit rate but are not widely used in clinical… (More)
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Highly Cited
1996
Highly Cited
1996
The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Diarrhea is a serious side effect that may prevent the administration of high doses of the antitumor drug Irinotecan… (More)
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1992
1992
To determine the efficacy of loperamide given with long- and short-course quinolone therapy for treating traveler's diarrhea, 142… (More)
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Highly Cited
1982
Highly Cited
1982
We have investigated the effect of loperamide (4 mg tds) on the continence to a standard volume of rectally infused saline and… (More)
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1980
1980
Effects of the currently marketed form of loperamide (Imodium capsules) that might relate to abuse potential were examined. Study… (More)
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