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Long QT syndrome type 3

 
National Institutes of Health

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2018
2018
BACKGROUND Eleclazine (GS-6615) is a sodium channel blocker designed to improve the selectivity for cardiac late Na+ current (INa… Expand
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Highly Cited
2016
Highly Cited
2016
Background Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for… Expand
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2016
2016
SCN5A is abundant in heart and has a major role in INa. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS… Expand
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Review
2014
Review
2014
Mammalian species express nine functional voltage-gated Na+ channels. Three of them, the cardiac-specific isoform Nav1.5 and the… Expand
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Review
2013
Review
2013
Over the last two decades, an increasing number of SCN5A mutations have been described in patients with long QT syndrome type 3… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(V)1.5, plays a pivotal… Expand
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2007
2007
The experiments investigated the applicability of two established criteria for arrhythmogenicity in Scn5a+/Δ and Scn5a+/− murine… Expand
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2005
2005
OBJECTIVE Congenital long QT syndrome type 3 (LQT3) is an inherited cardiac arrhythmia disorder due to mutations in the cardiac… Expand
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2004
2004
INTRODUCTION Brugada syndrome is characterized by sudden death secondary to malignant arrhythmias and the presence of ST segment… Expand
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2003
2003
Congenital long QT syndrome type 3 (LQT3) is caused by mutations in the gene SCN5A encoding the alpha-subunit of the cardiac Na… Expand
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