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Eleclazine (GS-6615) is a sodium channel blocker designed to improve the selectivity for cardiac late Na+ current (INa… Expand Congenital long QT syndrome type 3 (LQT3) is the third in frequency compared to the 15 forms known currently of congenital long… Expand Background Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for… Expand SCN5A is abundant in heart and has a major role in INa. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS… Expand Abstract Over the last two decades, an increasing number of SCN5A mutations have been described in patients with long QT… Expand Background—Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, NaV1.5, plays a pivotal… Expand The experiments investigated the applicability of two established criteria for arrhythmogenicity in Scn5a+/Δ and Scn5a+/− murine… Expand OBJECTIVES
The aim was to investigate at what age electrocardiographic characteristics of long QT syndrome type 3 (LQT3) and… Expand Introduction: Brugada syndrome is characterized by sudden death secondary to malignant arrhythmias and the presence of ST segment… Expand Congenital long QT syndrome type 3 (LQT3) is caused by mutations in the gene SCN5A encoding the α‐subunit of the cardiac Na… Expand