Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.
Simulated action potentials are consistent with those recorded experimentally and have a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential.
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart
The present study provides the first genome‐scale regional ionic channel expression profile in the mouse heart by using large‐scale real‐time RT‐PCR and two‐way hierarchical clustering analysis of the 71 genes successfully classified the six pools from the four distinct regions.
Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking
It is concluded that two Na+ channel isoforms are important for the functioning of the SA node: neuronal (putative Nav1.1) and cardiac Nav 1.5 isoform alone is involved in the propagation of the action potential from the SA nodes to the surrounding atrial muscle.
Organisation of the mouse sinoatrial node: structure and expression of HCN channels.
Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node
New evidence is provided that functional IP3R2s are expressed in the mouse SAN and could serve as an additional Ca2+-dependent mechanism in modulating cardiac pacemaker activity as well as other Ca2-dependent processes.
Generation of functional ion-channel tools by E3 targeting
The potential power of E3 targeting as a systematic method for producing gene-type specific ion-channel inhibitors for use in routine assays on cells or tissues from a range of species and having therapeutic potential is illustrated.
Modernized Classification of Cardiac Antiarrhythmic Drugs
Background: Among his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central to their clinical…
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase.
Neuronal Nitric Oxide Synthase Protects Against Myocardial Infarction–Induced Ventricular Arrhythmia and Mortality in Mice
The antiarrhythmic effect of nNOS involves inhibition of L-type Ca2+ channel activity and regulation of Ca2- handling proteins via S-nitrosylation.
Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2‐P2328S hearts
The present experiments investigate the atrial electrophysiology of homozygotic murine RyR2‐P2328S (RyR2S/S) hearts for ectopic triggering events and for conduction abnormalities that might provide a re‐entrant substrate.