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Lomustine

Known as: Chloroethylcyclo-hexylnitrosourea, cyclohexylchloroethylnitrosourea, Chloroethylcyclohexylnitrosourea 
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (11)

BCNYUBELD protocolBelustinBelustine
CCOM protocolCCV-AV protocolColonic NeoplasmsIn Blood

Broader (1)

Nitrosourea Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Successful treatment of low‐grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine
Anaplastic oligodendroglioma (OD) tumors, especially those with the combined loss of the short arm of chromosome 1 (1p) and the… 
Highly Cited
2000
Highly Cited
2000
Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for…
Although the efficacy of the nitrosourea-based combination chemotherapy procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N… 
Highly Cited
1998
Highly Cited
1998
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.
To determine whether loss of mismatch repair (MMR) confers sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea (CCNU… 
Highly Cited
1982
Highly Cited
1982
Role of Uteroglobin and Transglutaminase in Masking the Antigenicity of Implanting Rabbit Embryos *
ABSTRACT: Using rabbit as a model, the roles of uteroglobin (UG) and transglutaminase (TG) in masking the antigenicity of early… 
Highly Cited
1982
Highly Cited
1982
Modifications of DNA by different haloethylnitrosoureas.
The modification of DNA by the haloethylnitrosoureas is probably responsible for their antitumor activity. A current hypothesis… 
Highly Cited
1979
Highly Cited
1979
Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Poly(adenosine diphosphate ribose) polymerase, a chromatin-bound enzyme, was stimulated 150 to 200% after treatment of HeLa cells… 
Highly Cited
1975
Highly Cited
1975
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4…
Chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1… 
Highly Cited
1975
Highly Cited
1975
Comparative effects of three nitrosourea derivatives on mammalian cell cycle progression.
Three nitrosourea analogs, 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, and 1-trans-(2… 
Highly Cited
1975
Highly Cited
1975
Carbamoylation of amino acid, peptides, and proteins by nitrosoureas.
Incubation at approximately physiological conditions of amino acids, peptides, and proteins with 1-(2-chloroethyl)-3-cyclohexyl-1… 
Highly Cited
1972
Highly Cited
1972
Interaction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro.
The macromolecular binding of radioactivity from 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea, labeled with 14C in either the… 
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