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Lomustine

Known as: Chloroethylcyclo-hexylnitrosourea, cyclohexylchloroethylnitrosourea, Chloroethylcyclohexylnitrosourea 
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (11)

BCNYUBELD protocolBelustinBelustine
CCOM protocolCCV-AV protocolColonic NeoplasmsIn Blood

Broader (1)

Nitrosourea Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1983
1983
Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
The ability of three nitroimidazoles [SR-2508, misonidazole (MISO), and benznidazole] with differing octanol-water partition… 
Highly Cited
1979
Highly Cited
1979
Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Poly(adenosine diphosphate ribose) polymerase, a chromatin-bound enzyme, was stimulated 150 to 200% after treatment of HeLa cells… 
Highly Cited
1978
Highly Cited
1978
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Five permanent tumor cell lines derived originally from either a solid or an ascites biopsy of rat hepatoma exhibited… 
Highly Cited
1977
Highly Cited
1977
Chemotherapy for bronchogenic carcinoma. Methotrexate, doxorubicin, cyclophosphamide, and lomustine.
A combination chemotherapy (MACC) consisting of methotrexate, doxorubicin hydrochloride (Adriamycin), cyclophosphamide, and… 
Highly Cited
1975
Highly Cited
1975
Comparative effects of three nitrosourea derivatives on mammalian cell cycle progression.
Three nitrosourea analogs, 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, and 1-trans-(2… 
Highly Cited
1975
Highly Cited
1975
Carbamoylation of amino acid, peptides, and proteins by nitrosoureas.
Incubation at approximately physiological conditions of amino acids, peptides, and proteins with 1-(2-chloroethyl)-3-cyclohexyl-1… 
Highly Cited
1975
Highly Cited
1975
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4…
Chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1… 
Highly Cited
1972
Highly Cited
1972
Interaction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro.
The macromolecular binding of radioactivity from 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea, labeled with 14C in either the… 
1970
1970
The uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma.
The antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) against the murine ependymoblastoma, glioma 26, and… 
1968
1968
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.
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