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Lomustine

Known as: Chloroethylcyclo-hexylnitrosourea, cyclohexylchloroethylnitrosourea, Chloroethylcyclohexylnitrosourea 
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (11)

BCNYUBELD protocolBelustinBelustine
CCOM protocolCCV-AV protocolColonic NeoplasmsIn Blood

Broader (1)

Nitrosourea Compounds

Papers overview

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1986
1986
DNA modification by sulfur mustards and nitrosoureas and repair of these lesions.
In this chapter, the nature and significance of DNA modifications caused by a particular mutagenic agent, chloroethyl ethyl… 
1982
1982
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has… 
1982
1982
Autologous bone marrow transplantation in the therapy of small cell carcinoma of the lung.
Ten patients with small cell carcinoma of the lung were entered into a chemotherapeutic treatment program consisting of… 
Highly Cited
1979
Highly Cited
1979
Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Poly(adenosine diphosphate ribose) polymerase, a chromatin-bound enzyme, was stimulated 150 to 200% after treatment of HeLa cells… 
1978
1978
Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.
Four chloroethylnitrosoureas with differing degrees of carbamoylating activity were compared for their effects on incorporation… 
1977
1977
Active site specific inactivation of chymotrypsin by cyclohexyl isocyanate formed during degradation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Prolonged incubation of 1-(2-chloroethyl)-3-([1-14C]cyclohexyl)-1-nitrosourea with chymotrypsin resulted in covalent modification… 
Highly Cited
1975
Highly Cited
1975
2-chloroethanol formation as evidence for a 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4…
Chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1… 
1972
1972
A comparative study of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and imidazole carboxamide (NSC 45388) with vincristine (NSC 67574) in the palliation of disseminated malignant melanoma…
Summary The effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (NSC 79037) were compared to those of a combination of… 
1970
1970
The uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma.
The antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) against the murine ependymoblastoma, glioma 26, and… 
1968
1968
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.