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Lomustine

Known as: Chloroethylcyclo-hexylnitrosourea, cyclohexylchloroethylnitrosourea, Chloroethylcyclohexylnitrosourea 
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Treatment options for recurrent glioblastoma are scarce, with second-line chemotherapy showing only modest activity… Expand
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Highly Cited
2014
Highly Cited
2014
PURPOSE Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology… Expand
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Highly Cited
2013
Highly Cited
2013
PURPOSE Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE This phase III open-label study compared the efficacy and safety of enzastaurin versus lomustine in patients with… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND/METHODS Gliomas are common malignant neoplasms of the central nervous system. Among the major subtypes of gliomas… Expand
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Highly Cited
1995
Highly Cited
1995
PURPOSE In a previous randomized trial, the addition of adjuvant chemotherapy to postoperative radiotherapy proved beneficial in… Expand
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Highly Cited
1994
Highly Cited
1994
It has previously been reported in a single-institution trial that progression-free survival of children with medulloblastoma… Expand
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