Lomustine

Known as: Chloroethylcyclo-hexylnitrosourea, cyclohexylchloroethylnitrosourea, Chloroethylcyclohexylnitrosourea 
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Treatment options for recurrent glioblastoma are scarce, with second-line chemotherapy showing only modest activity… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE This phase III open-label study compared the efficacy and safety of enzastaurin versus lomustine in patients with… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Temozolomide (TMZ) is an alkylating agent licensed for treatment of high-grade glioma (HGG). No prospective comparison… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are treated with surgery and radiotherapy (RT) at… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND/METHODS Gliomas are common malignant neoplasms of the central nervous system. Among the major subtypes of gliomas… (More)
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Highly Cited
1995
Highly Cited
1995
PURPOSE In a previous randomized trial, the addition of adjuvant chemotherapy to postoperative radiotherapy proved beneficial in… (More)
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Highly Cited
1981
Highly Cited
1981
The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were… (More)
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