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LYN gene

Known as: v-YES-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog Gene, ONCOGENE LYN, V-YES-1 YAMAGUCHI SARCOMA VIRAL RELATED ONCOGENE HOMOLOG 
This gene plays a role in signal transduction.
National Institutes of Health

Related topics

Related topics

10 relations
Cell Differentiation processCell ProliferationHomo sapiensLYN protein, human

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LYN wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Jak2 inhibition deactivates Lyn kinase through the SET–PP2A–SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
Chronic myelogenous leukemia (CML) patients treated with imatinib mesylate (IM) become drug resistant by mutations within the… 
Highly Cited
2005
Highly Cited
2005
FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane
The aggregation of high affinity IgE receptors (Fcɛ receptor I [FcɛRI]) on mast cells is potent stimulus for the release of… 
Highly Cited
2004
Highly Cited
2004
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
The hepatitis C virus (HCV) non-structural NS5A protein has been shown to associate with a variety of cellular signalling… 
Highly Cited
2001
Highly Cited
2001
Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
Stem cell factor (SCF) binds to c-Kit and is an important mediator of survival, growth, and function of hematopoietic progenitor… 
Highly Cited
2001
Highly Cited
2001
Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn
Highly Cited
1999
Highly Cited
1999
Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor gamma-chain, Fyn, and Lyn to activate human platelets.
The adhesion molecule von Willebrand factor (vWF) activates platelets upon binding 2 surface receptors, glycoprotein (GP) Ib-V-IX… 
Highly Cited
1997
Highly Cited
1997
Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.
Signaling through the high affinity IgE receptor (Fc epsilon RI) on mast cells and basophils results in rapid increases in… 
Highly Cited
1994
Highly Cited
1994
Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.
Many proteins involved in intracellular signal transduction contain a small, 50‐60 amino acid domain, termed the Src homology 3… 
Highly Cited
1994
Highly Cited
1994
Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn
The high affinity immunoglobulin G (IgG) receptor Fc gamma RI (CD64) is expressed constitutively on monocytes and macrophages… 
Highly Cited
1994
Highly Cited
1994
Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.
Bruton's tyrosine kinase (Btk) is a recently described B-cell-specific tyrosine kinase. Mutations in this gene lead to human X… 
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