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LYN gene

Known as: v-YES-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog Gene, ONCOGENE LYN, V-YES-1 YAMAGUCHI SARCOMA VIRAL RELATED ONCOGENE HOMOLOG 
This gene plays a role in signal transduction.
National Institutes of Health

Related topics

Related topics

10 relations
Cell Differentiation processCell ProliferationHomo sapiensLYN protein, human

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LYN wt Allele

Papers overview

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2012
2012
Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis
Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine… 
Highly Cited
2011
Highly Cited
2011
Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells
In B-cell chronic lymphocytic leukemia (B-CLL) cells, Lyn, a tyrosine kinase belonging to the Src family, is overexpressed and… 
Review
2010
Review
2010
A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells
Resistance to the BCR-ABL tyrosine kinase inhibitor imatinib poses a pressing challenge in treating chronic myeloid leukemia (CML… 
2010
2010
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association
The Src-family tyrosine kinase Lyn has a role in signal transduction at the cytoplasmic face of the plasma membrane upon… 
Highly Cited
2006
Highly Cited
2006
Csk-binding Protein Mediates Sequential Enzymatic Down-regulation and Degradation of Lyn in Erythropoietin-stimulated Cells*
We have shown previously that the Src family kinase Lyn is involved in differentiation signals emanating from activated… 
Highly Cited
2006
Highly Cited
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… 
Highly Cited
2002
Highly Cited
2002
Association of GPI-Anchored Protein TAG-1 with Src-Family Kinase Lyn in Lipid Rafts of Cerebellar Granule Cells
We have demonstrated that antibody-mediated crosslinking of GPI-anchored TAG-1 induced activation of src-family kinase Lyn and… 
2002
2002
Lyn Tyrosine Kinase Is Important for IL-5-Stimulated Eosinophil Differentiation1
IL-5 plays a pivotal role in growth and differentiation of eosinophils. The signal transduction mechanism of IL-5Rα is largely… 
Highly Cited
1995
Highly Cited
1995
Selective Regulation of Lyn Tyrosine Kinase by CD45 in Immature B Cells (*)
It has been well established that protein-tyrosine phosphatase CD45 is critically involved in the regulation of initial tyrosine… 
1994
1994
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.
Proteins that bind to discrete domains of the Blk, Fyn, Lyn, and Btk protein tyrosine kinases were examined in pre-B cells that… 
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