Skip to search formSkip to main contentSkip to account menu

LY96 gene

Known as: MD-2, MD2, MD2 PROTEIN 
National Institutes of Health

Related topics

Related topics

2 relations
LY96 protein, humanLymphocyte Antigen 96

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation1
It has been shown that lactate induces insulin resistance. However, the underlying mechanisms have not been well understood… 
Highly Cited
2007
Highly Cited
2007
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2*
Inflammation under sterile conditions is not well understood despite its importance in trauma and autoimmune disease. To… 
Highly Cited
2006
Highly Cited
2006
Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering1
LPS, a principal membrane component in Gram-negative bacteria, is recognized by a receptor complex consisting of TLR4 and MD-2… 
Highly Cited
2004
Highly Cited
2004
Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
Host proinflammatory responses to minute amounts of endotoxins derived from many Gram-negative bacteria require the interaction… 
Highly Cited
2003
Highly Cited
2003
Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness 1
Cellular responses to LPS are mediated by a cell surface receptor complex consisting of Toll-like receptor 4 (TLR4), MD-2, and… 
Highly Cited
2002
Highly Cited
2002
Monomeric Recombinant MD-2 Binds Toll-like Receptor 4 Tightly and Confers Lipopolysaccharide Responsiveness*
In order to mediate cellular response to lipopolysaccharide (LPS), Toll-like receptor (TLR) 4 must interact with MD-2, a secreted… 
Highly Cited
2002
Highly Cited
2002
Identification of LPS-binding peptide fragment of MD-2, a toll-receptor accessory protein.
Members of the toll-like receptor family are crucial in recognition of microbial pathogens as part of innate immune response. MD… 
Highly Cited
2001
Highly Cited
2001
MD-2 binds to bacterial lipopolysaccharide.
Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2… 
Highly Cited
2001
Highly Cited
2001
MD-2 Enables Toll-Like Receptor 2 (TLR2)-Mediated Responses to Lipopolysaccharide and Enhances TLR2-Mediated Responses to Gram-Positive and Gram-Negative Bacteria and Their Cell Wall Components1
MD-2 is associated with Toll-like receptor 4 (TLR4) on the cell surface and enables TLR4 to respond to LPS. We tested whether MD… 
Highly Cited
2001
Highly Cited
2001
N-Linked Glycosylations at Asn26 and Asn114 of Human MD-2 Are Required for Toll-Like Receptor 4-Mediated Activation of NF-κB by Lipopolysaccharide
MD-2 is physically associated with Toll-like receptor 4 (TLR4) and is required for TLR4-mediated LPS signaling. Western blotting… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)