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LY2090314

Known as: 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione, LY 2090314, GSK-3 Inhibitor LY2090314 
An inhibitor of glycogen synthase kinase-3 (GSK-3), with potential antineoplastic activity. Upon administration, LY2090314 binds to and inhibits GSK… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Inibição da GSK-3 afeta negativamente a regulação da maturação in vitro de ovócitos bovinos
A glicogênio sintase quinase-3 (GSK-3) é uma enzima que atua em diversas cascatas de transdução de sinal, participando de várias… 
2014
2014
Consecuencias neurológicas de la inhibición sostenida de GSK-3 en cerebro adulto
Se cree que un incremento de actividad GSK-3 contribuye a la etiologia de enfermedades como la enfermedad de Alzheimer, el… 
2013
2013
Role of GSK-3 β in Neurodegenerative Disorders
Review
2013
Review
2013
HyperpHospHoryl Ation of t Au by GsK-3 β in AlzHeimer's diseAse: tHe inter Action of A β And spHinGolipid mediA tors As A tHer Apeutic t ArGet
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the extracellular deposits of β amyloid… 
2012
2012
Efeito da inibição da AKT na maturação in vitro de ovócitos bovinos
A gligogênio-sintase-quinase-3 (GSK-3) é uma enzima conservada nos resíduos de serina/treonina, regulada por fosforilação na… 
2011
2011
A phase I dose-escalation, pharmacokinetic (PK), and pharmacodynamic (PD) evaluation of intravenous LY2090314 a GSK3 inhibitor administered in combination with pemetrexed and carboplatin.
3030 Background: LY2090314 (LY) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many… 
2010
2010
Clinical Cancer esearch an Cancer Biology ogen Synthase Kinase-3 β : A Prognostic Marker and a R ential Therapeutic Target in Human Bladder Cancer
wnloade pose:Although recent studies have shown glycogen synthase kinase-3β (GSK-3β), a serine/threonine , as a positive… 
2008
2008
Effect of GSK-3 overactivation on neurofilament phosphorylation
SummaryIn this study, we studied the effect of glycogen synthase kinase-3 (GSK-3) overactivation on neurofilament phosphorylation… 
2004
2004
Involvement of GSK-3 b in TW EAK-mediated NF-j B activation
Glycogen synthase kinase-3b (GSK-3b) is a key component of several signaling pathways. We found that a short variant of ‘TNF-like… 
Highly Cited
2000
Highly Cited
2000
Two Different Signal Transduction Pathways Are Implicated in the Regulation of Initiation Factor 2B Activity in Insulin-like Growth Factor-1-stimulated Neuronal Cells*
Eukaryotic initiation factor eIF-2B plays an important role in translation regulation and has been suggested to be implicated in… 
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