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LY2090314

Known as: 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione, LY 2090314, GSK-3 Inhibitor LY2090314 
An inhibitor of glycogen synthase kinase-3 (GSK-3), with potential antineoplastic activity. Upon administration, LY2090314 binds to and inhibits GSK… Expand
National Institutes of Health

Papers overview

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2018
2018
BackgroundNeuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB… Expand
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2016
2016
Development of protein kinase inhibitors is a focus of many drug discovery programs. A major problem, however, is the limited… Expand
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2016
2016
Abstract This open-label, Phase-2 study investigated the safety of LY2090314 (GSK-3 inhibitor) in AML patients. Twenty patients… Expand
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2015
2015
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin… Expand
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2015
2015
SummaryPurpose LY2090314 (LY) is a glycogen synthase kinase 3 inhibitor with preclinical efficacy in xenograft models when… Expand
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2014
2014
The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome… Expand
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2013
2013
LY2090314 (3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3… Expand
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Highly Cited
2011
Highly Cited
2011
Glycogen synthase kinase-3 (GSK-3) unique position in modulating the function of a diverse series of proteins in combination with… Expand
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2005
2005
In this study, we studied the effect of glycogen synthase kinase-3 (GSK-3) overactivation on neurofilament phosphorylation in… Expand
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2000
2000
Eukaryotic initiation factor eIF-2B plays an important role in translation regulation and has been suggested to be implicated in… Expand
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