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An anatomically comprehensive atlas of the adult human brain transcriptome
A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function. Expand
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders 1 1 These authors contributed equally to this work.
A direct correlation has been established between the progressive involvement of the neocortical areas and the increasing severity of dementia, suggesting that pathological tau proteins are reliable marker of the neurodegenerative process. Expand
Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains
Atlas of the brain of the C57BL/6 mouse: 49 Nissl (Cresyl Violet)- and 6 myelin (Luxol-Fast Blue)-stained plates for each plate: full art, half lineart, and list of relevant structures, and index of structures. Expand
Primary age-related tauopathy (PART): a common pathology associated with human aging
A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Expand
Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting
This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses. Expand
Human cingulate cortex: Surface features, flat maps, and cytoarchitecture
  • B. Vogt, Esther A. Nimchinsky, L. Vogt, P. Hof
  • Biology, Medicine
  • The Journal of comparative neurology
  • 28 August 1995
The surface morphology and cytoarchitecture of human cingulate cortex was evaluated in the brains of 27 neurologically intact individuals to provide structural underpinnings for interpreting functional imaging studies of the human medial surface. Expand
Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images
A novel system for automated detection, shape analysis and classification of dendritic spines from laser scanning microscopy (LSM) images that directly addresses limitations in quantifying three-dimensional spine shapes with sufficient precision to distinguish morphologic types, and sufficient throughput for robust statistical analysis is introduced. Expand
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of A&bgr; plaques and neurofibrillary tangles. Expand
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the negative feedback regulation of hypothalamic-pituitary-adrenal (HPA) activity during physiologic andExpand
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus
Two studies subjected rats to acute or chronic restraint stress and assessed the proliferation, survival and differentiation of newly born cells in the dentate gyrus may help understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress. Expand