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LY 315920
Known as:
LY-315920
, LY315920
, LY333013
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
varespladib methyl
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)
Mátyás A Bittenbinder
,
C. Zdenek
,
+5 authors
B. Fry
Toxins
2018
Corpus ID: 54465548
Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long…
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2018
2018
Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom
M. Lewin
,
L. Gilliam
,
+4 authors
J. Gutiérrez
Toxins
2018
Corpus ID: 53876002
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be…
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Highly Cited
2016
Highly Cited
2016
Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation
M. Lewin
,
S. Samuel
,
J. Merkel
,
P. Bickler
Toxins
2016
Corpus ID: 857554
Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a…
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2014
2014
Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells
Z. Dong
,
J. Meller
,
+4 authors
Sha Lu
International journal of oncology
2014
Corpus ID: 17264293
Lung cancer is the leading cause of cancer death worldwide. There is an urgent need for early diagnostic tools and novel…
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Highly Cited
2008
Highly Cited
2008
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.
R. Oslund
,
N. Cermak
,
M. Gelb
Journal of medicinal chemistry
2008
Corpus ID: 16955176
We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and…
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Highly Cited
2007
Highly Cited
2007
Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: application to the preparation of indole inhibitors of phospholipase A2.
R. Sanz
,
M. Castroviejo
,
V. Guilarte
,
A. Perez
,
F. J. Fañanás
The Journal of organic chemistry
2007
Corpus ID: 12176022
An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting…
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Highly Cited
2005
Highly Cited
2005
A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis.
J. Bradley
,
A. Dmitrienko
,
+5 authors
G. Sides
The Journal of rheumatology
2005
Corpus ID: 36085075
OBJECTIVE To evaluate the efficacy and safety of a selective inhibitor of secretory phospholipase (sPLA2), LY333013, in the…
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2005
2005
Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.
Y. Hori
,
S. Spurr-Michaud
,
C. L. Russo
,
P. Argüeso
,
I. Gipson
Investigative ophthalmology & visual science
2005
Corpus ID: 17613803
PURPOSE How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood…
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Highly Cited
1999
Highly Cited
1999
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti…
D. Snyder
,
N. Bach
,
+12 authors
J. Fleisch
The Journal of pharmacology and experimental…
1999
Corpus ID: 31552191
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic…
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Highly Cited
1996
Highly Cited
1996
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.
S. Draheim
,
N. Bach
,
+15 authors
J. Wery
Journal of medicinal chemistry
1996
Corpus ID: 32658320
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We…
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