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LY 315920

Known as: LY-315920, LY315920, LY333013 
National Institutes of Health

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Related topics

1 relation

Broader (1)

varespladib methyl

Papers overview

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Highly Cited
2018
Highly Cited
2018
Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)
Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long… 
2018
2018
Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be… 
Highly Cited
2016
Highly Cited
2016
Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation
Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a… 
2014
2014
Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells
Lung cancer is the leading cause of cancer death worldwide. There is an urgent need for early diagnostic tools and novel… 
Highly Cited
2008
Highly Cited
2008
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.
We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and… 
Highly Cited
2007
Highly Cited
2007
Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: application to the preparation of indole inhibitors of phospholipase A2.
An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting… 
Highly Cited
2005
Highly Cited
2005
A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis.
OBJECTIVE To evaluate the efficacy and safety of a selective inhibitor of secretory phospholipase (sPLA2), LY333013, in the… 
2005
2005
Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.
PURPOSE How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood… 
Highly Cited
1999
Highly Cited
1999
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti…
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic… 
Highly Cited
1996
Highly Cited
1996
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We… 
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