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LY 2121260

Known as: LY-2121260, LY2121260 
 
National Institutes of Health

Papers overview

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2015
2015
Lack of glibenclamide response in a case of permanent neonatal diabetes caused by incomplete inactivation of glucokinase.
BACKGROUND Hypoglycaemic drugs that close the KATP channel have been tested in patients with permanent neonatal diabetes due to… Expand
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Review
2014
Review
2014
Recent updates on glucokinase activators for the treatment of type 2 diabetes mellitus.
Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose homeostasis primarily through its regulatory… Expand
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2012
2012
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260.
The glucose phosphorylating enzyme glucokinase plays a crucial role in stimulus-secretion coupling in pancreatic beta cells and… Expand
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2009
2009
Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells
Aims/hypothesisGlucokinase (GK), an enzyme that phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor… Expand
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Highly Cited
2005
Highly Cited
2005
A novel glucokinase activator modulates pancreatic islet and hepatocyte function.
The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report here the effects of a novel… Expand
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