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LRRK1 gene

Known as: RIPK6, LEUCINE-RICH REPEAT KINASE 1, FLJ23119 
National Institutes of Health

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LRRK2 gene

Papers overview

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Highly Cited
2018
Highly Cited
2018
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
Importance Pathogenic variants in LRRK2 are a relatively common genetic cause of Parkinson disease (PD). Currently, the molecular… 
2018
2018
Biomechanical Control of Lysosomal Secretion Via the VAMP7 Hub: A Tug-of-War between VARP and LRRK1
2017
2017
Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic… 
2016
2016
Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity
Background Osteosclerotic metaphyseal dysplasia (OSMD) is a unique form of osteopetrosis characterised by severe osteosclerosis… 
2015
2015
Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation
ABSTRACT Autophagy is a conserved process that enables catabolic and degradative pathways. Rab family proteins, which are active… 
2015
2015
LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends
ABSTRACT The binding of ligand to epidermal growth factor receptor (EGFR) causes the receptor to become activated and stimulates… 
Highly Cited
2014
Highly Cited
2014
Differential protein–protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
Genetic studies show that LRRK2, and not its closest paralogue LRRK1, is linked to Parkinson's disease. To gain insight into the… 
2012
2012
EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR
Endocytosis and subsequent delivery of activated EGFR to lysosomes are essential for the termination of EGFR signaling. It is… 
Highly Cited
2011
Highly Cited
2011
Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor
Activation of the epidermal growth factor receptor (EGFR) not only initiates multiple signal-transduction pathways, including the… 
2010
2010
Heterodimerization of Lrrk1–Lrrk2: Implications for LRRK2-associated Parkinson disease
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