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LRRC8A gene

Known as: FLJ10337, LRRC8A, LEUCINE-RICH REPEAT-CONTAINING PROTEIN 8A 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Biophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels
Review
2019
Review
2019
More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels
Abstract The volume-regulated anion channel (VRAC) is a key player in the volume regulation of vertebrate cells. This… 
Highly Cited
2018
Highly Cited
2018
Cryo-EM structures of the human volume-regulated anion channel LRRC8
Maintenance of cell volume against osmotic change is crucial for proper cell functions. Leucine-rich repeat-containing 8 proteins… 
Highly Cited
2018
Highly Cited
2018
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Insulin secretion is initiated by activation of voltage-gated Ca2+ channels (VGCC) to trigger Ca2+-mediated insulin vesicle… 
Highly Cited
2017
Highly Cited
2017
Molecular composition and heterogeneity of the LRRC8‐containing swelling‐activated osmolyte channels in primary rat astrocytes
The volume‐regulated anion channel (VRAC) is a swelling‐activated chloride channel that is permeable to inorganic anions and a… 
Review
2015
Review
2015
The volume-regulated anion channel is formed by LRRC8 heteromers – molecular identification and roles in membrane transport and physiology
Abstract Cellular volume regulation is fundamental for numerous physiological processes. The volume-regulated anion channel, VRAC… 
Review
2015
Review
2015
TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume.
Highly Cited
2014
Highly Cited
2014
LRRC8A protein is indispensable for swelling‐activated and ATP‐induced release of excitatory amino acids in rat astrocytes
Swelling‐activated release of amino acids in the CNS is thought to be mediated by an unidentified volume‐regulated anion channel… 
2014
2014
Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system.
Highly Cited
2004
Highly Cited
2004
LRRC8 involved in B cell development belongs to a novel family of leucine‐rich repeat proteins
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