Transient receptor potential cation channels in disease.
- B. Nilius, G. Owsianik, T. Voets, J. A. Peters
- BiologyPhysiological Reviews
- 2007
An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
Ion channels and their functional role in vascular endothelium.
- B. Nilius, G. Droogmans
- BiologyPhysiological Reviews
- 10 January 2001
Evidence is presented for the involvement of ion channels in endothelial cell functions controlled by intracellular Ca(2+) signals, such as the production and release of many vasoactive factors, e.g., nitric oxide and PGI(2).
Calcium absorption across epithelia.
- J. Hoenderop, B. Nilius, R. Bindels
- BiologyPhysiological Reviews
- 2005
The characteristics of epithelial Ca(2+) transport in general are described and in particular the distinctive features and the physiological relevance of the new epithelialCa(2+)-transporting channels accumulating in a comprehensive model for epithelia absorption are highlighted.
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
- T. Voets, G. Droogmans, U. Wissenbach, Annelies Janssens, V. Flockerzi, B. Nilius
- BiologyNature
- 12 August 2004
Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
- Hiroyuki Watanabe, J. Vriens, J. Prenen, G. Droogmans, T. Voets, B. Nilius
- BiologyNature
- 24 July 2003
It is shown that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids.
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives*
- Hiroyuki Watanabe, John B Davis, B. Nilius
- BiologyJournal of Biological Chemistry
- 19 April 2002
It is concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel.
The transient receptor potential family of ion channels
- B. Nilius, G. Owsianik
- BiologyGenome Biology
- 17 March 2011
Mutations in several TRP genes have been implicated in diverse pathological states, including neurodegenerative disorders, skeletal dysplasia, kidney disorders and pain, and ongoing research may help find new therapies for treatments of related diseases.
Properties of volume-regulated anion channels in mammalian cells.
- B. Nilius, J. Eggermont, T. Voets, G. Buyse, V. Manolopoulos, G. Droogmans
- BiologyProgress in Biophysics and Molecular Biology
- 1997
Amazing chloride channels: an overview.
- B. Nilius, G. Droogmans
- BiologyActa Physiologica Scandinavica
- 1 February 2003
The role of Cl- channels in various diseases is discussed and the pathological phenotypes observed in knockout mice models are described, including their involvement in transepithelial transport, pH regulation of intracellular organelles, regulation of excitability and volume regulation.
TRP channels.
- M. Gees, G. Owsianik, B. Nilius, T. Voets
- BiologyComprehensive Physiology
- 2012
A brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels is provided.
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