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Transient receptor potential cation channels in disease.
TLDR
An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
Calcium absorption across epithelia.
TLDR
The characteristics of epithelial Ca(2+) transport in general are described and in particular the distinctive features and the physiological relevance of the new epithelialCa(2+)-transporting channels accumulating in a comprehensive model for epithelia absorption are highlighted.
Ion channels and their functional role in vascular endothelium.
TLDR
Evidence is presented for the involvement of ion channels in endothelial cell functions controlled by intracellular Ca(2+) signals, such as the production and release of many vasoactive factors, e.g., nitric oxide and PGI(2).
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
TLDR
It is shown that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids.
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
TLDR
Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives*
TLDR
It is concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel.
TRP channels: an overview.
TLDR
The present review summarizes the most pertinent recent evidence regarding the structural and functional properties of TRP channels, focusing on the regulation and physiology of mammalian TRPs.
TRPA1 acts as a cold sensor in vitro and in vivo
TLDR
It is concluded that TRPA1 acts as a major sensor for noxious cold, and a specific subset of cold-sensitive trigeminal ganglion neurons that is absent inTRPA1-deficient mice are identified.
Amazing chloride channels: an overview.
TLDR
The role of Cl- channels in various diseases is discussed and the pathological phenotypes observed in knockout mice models are described, including their involvement in transepithelial transport, pH regulation of intracellular organelles, regulation of excitability and volume regulation.
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