Transient receptor potential cation channels in disease.
An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
Ion channels and their functional role in vascular endothelium.
Evidence is presented for the involvement of ion channels in endothelial cell functions controlled by intracellular Ca(2+) signals, such as the production and release of many vasoactive factors, e.g., nitric oxide and PGI(2).
Calcium absorption across epithelia.
The characteristics of epithelial Ca(2+) transport in general are described and in particular the distinctive features and the physiological relevance of the new epithelialCa(2+)-transporting channels accumulating in a comprehensive model for epithelia absorption are highlighted.
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
- T. Voets, G. Droogmans, U. Wissenbach, Annelies Janssens, V. Flockerzi, B. Nilius
- 12 August 2004
Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
It is shown that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids.
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives*
It is concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel.
The transient receptor potential family of ion channels
Mutations in several TRP genes have been implicated in diverse pathological states, including neurodegenerative disorders, skeletal dysplasia, kidney disorders and pain, and ongoing research may help find new therapies for treatments of related diseases.
Properties of volume-regulated anion channels in mammalian cells.
Amazing chloride channels: an overview.
The role of Cl- channels in various diseases is discussed and the pathological phenotypes observed in knockout mice models are described, including their involvement in transepithelial transport, pH regulation of intracellular organelles, regulation of excitability and volume regulation.