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LIPG protein, human

Known as: EDL, Endothelial Cell-Derived Lipase, Lipoprotein Lipase H 
Endothelial lipase (500 aa, ~57 kDa) is encoded by the human LIPG gene. This protein is involved in the hydrolysis of triglycerides, phospholipids… 
National Institutes of Health

Related topics

Related topics

11 relations
Cholesterol HomeostasisEnzyme GeneEsterase GeneExtracellular Space

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.
Elevated plasma concentrations of HDL cholesterol (HDL-C) are associated with protection from atherosclerotic cardiovascular… 
Highly Cited
2005
Highly Cited
2005
NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program
Activation of the transcription factor NF-κB is critical for the tumor necrosis factor-α (TNF-α)-induced inflammatory response… 
Highly Cited
2005
Highly Cited
2005
Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis
Background Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C… 
Review
2004
Review
2004
Genetic Basis of Atherosclerosis: Part I: New Genes and Pathways
Knowledge of genetic factors in the etiology of coronary heart disease has not so far been adequately utilized in attempts to… 
Highly Cited
2003
Highly Cited
2003
Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.
Endothelial lipase (EL) is a recently discovered member of the lipoprotein lipase gene family that hydrolyzes HDL phospholipids… 
Highly Cited
2003
Highly Cited
2003
Endothelial Cells Secrete Triglyceride Lipase and Phospholipase Activities in Response to Cytokines as a Result of Endothelial Lipase
Abstract— The endothelium interacts extensively with lipids and lipoproteins, but there are very few data regarding the ability… 
Highly Cited
2003
Highly Cited
2003
Endogenously Produced Endothelial Lipase Enhances Binding and Cellular Processing of Plasma Lipoproteins via Heparan Sulfate Proteoglycan-mediated Pathway*
Endothelial lipase (EL) is a new member of the triglyceride lipase gene family, which includes lipoprotein lipase (LpL) and… 
Highly Cited
2002
Highly Cited
2002
Identification of Genetic Variants in Endothelial Lipase in Persons With Elevated High-Density Lipoprotein Cholesterol
Background—Elevated high-density lipoprotein cholesterol (HDL-C) is associated with reduced risk of cardiovascular disease, and… 
Highly Cited
1983
Highly Cited
1983
Relationship of plasma HDL-cholesterol to testosterone, estradiol, and sex-hormone-binding globulin levels in men and women.
Highly Cited
1980
Highly Cited
1980
Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man.
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