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LGR4 gene

Known as: G PROTEIN-COUPLED RECEPTOR 48, GPR48, leucine-rich repeat containing G protein-coupled receptor 4 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The Interplay of MicroRNA-34a, LGR4, EMT-Associated Factors, and MMP2 in Regulating Uveal Melanoma Cells.
Purpose MicroRNA-34a (miR-34a) has been implicated in many biological processes. It is downregulated in uveal melanoma, and… 
2018
2018
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
2017
2017
Lgr4 Expression in Osteoblastic Cells Is Suppressed by Hydrogen Peroxide Treatment
LGR4 is expressed in bone and has been shown to be involved in bone metabolism. Oxidative stress is one of the key issues in… 
2016
2016
MiR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression.
Prostate cancer is the most common solid-organ malignancy and the second leading cause of cancer-related death in males. The… 
2015
2015
Engineering High-Potency R-spondin Adult Stem Cell Growth Factors
Secreted R-spondin proteins (RSPOs1–4) function as adult stem cell growth factors by potentiating Wnt signaling. Simultaneous… 
2014
2014
Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway
G protein-coupled receptor 48 (Gpr48/Lgr4) is essential to regulate the development of multiple tissues in mice. The notion that… 
2014
2014
LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver.
The circadian clock plays an important role in the liver by regulating the major aspects of energy metabolism. Currently, it is… 
2012
2012
LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis
In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development… 
2009
2009
Inhibitory effect of shRNA targeting GPR48 on invasion and metastasis of human cervical carcinoma cell line HeLa.
BACKGROUND AND OBJECTIVE GPR48 regulates invasion and metastasis of cancer cells by linking Gs protein to stimulate intracellular… 
2006
2006
Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor.
GPR48, also known as leucine-rich repeat (LRR)-containing G-protein-coupled receptor 4 (LGR4), is a member of the G-protein… 
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