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LG 268

Known as: LG-268, LG268 
National Institutes of Health

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1 relation

Broader (1)

Organic Chemicals

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Inflammatory Mediators Increase SUMOylation of Retinoid X Receptor α in a c-Jun N-Terminal Kinase–Dependent Manner in Human Hepatocellular Carcinoma Cells
Retinoid X receptor α [RXRα; nuclear receptor (NR)2B1] is a crucial regulator in the expression of a broad array of hepatic genes… 
2013
2013
Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice
Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sex-specific… 
Highly Cited
2010
Highly Cited
2010
Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States and is nearly always fatal. Whereas… 
Highly Cited
2005
Highly Cited
2005
Retinoids Potentiate Peroxisome Proliferator-Activated Receptor γ Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myeloid Cells
Nuclear hormone receptors have been shown to be important transcription factors for regulating lipid metabolism in myeloid cells… 
2004
2004
Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice*
Rexinoids and thiazolidinediones (TZDs) are two classes of nuclear receptor ligands that induce insulin sensitization in diabetic… 
Highly Cited
2003
Highly Cited
2003
The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor.
Uptake and transplacental transfer of fatty acids is essential for fetal development. Human adipophilin and its murine ortholog… 
2001
2001
Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.
Retinoic acid (RA) inhibits hepatic macrophage (HM) cytokine expression, and retinoids are depleted in alcoholic liver disease… 
Highly Cited
2000
Highly Cited
2000
Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells.
During liver injury, hepatic stellate cells (HSC) acquire a myofibroblast-like phenotype associated with reduction of lipid… 
Highly Cited
1999
Highly Cited
1999
c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-γ1 and Negatively Regulates Its Transcriptional Activity.
The peroxisome proliferator-activated receptor-γ (PPARγ) transcription factor plays a pivotal role in adipocyte differentiation… 
Highly Cited
1997
Highly Cited
1997
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
TNF-alpha has been shown to be an important mediator of insulin resistance linked to obesity. This cytokine induces insulin… 
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