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Breast cancer (BC) was considered an immunologically silent tumor, however recent findings suggest that immune cells present in… Expand LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the… Expand Mitochondrial dysfunction is associated with insulin resistance and diabetes. We previously showed that retinoid X receptor… Expand As the promiscuous partner of heterodimeric associations, retinoid X receptors (RXRs) play a key role within the Nuclear Receptor… Expand The retinoid X receptor (RXR) contributes to the regulation of diverse biological pathways via its role as a heterodimeric… Expand The increasing prevalence of obesity is a fundamental contributor to the growing prevalence of the metabolic syndrome. Rexinoids… Expand Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such… Expand Benzofused heterocyclic analogs of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to… Expand New RXR-selective modulators possessing a 6-fluoro trienoic acid moiety (6Z olefin) or a fluorinated/heterocyclic-substituted… Expand Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to… Expand