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LETM1 gene

Known as: Mdm38 homolog (yeast), LETM1, LEUCINE ZIPPER/EF-HAND-CONTAINING TRANSMEMBRANE PROTEIN 1 
National Institutes of Health

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LETM2 geneLETMD1 gene

Papers overview

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Highly Cited
2014
Highly Cited
2014
LETM1‐dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation
Dysregulation of mitochondrial Ca2+‐dependent bioenergetics has been implicated in various pathophysiological settings, including… 
Highly Cited
2013
Highly Cited
2013
Trypanosome Letm1 Protein Is Essential for Mitochondrial Potassium Homeostasis*
Background: Letm1 is a mitochondrial protein attributed disparate roles, including cation/proton antiport and translation… 
Review
2012
Review
2012
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.
Originally identified as a key element of mitochondrial volume homeostasis through regulation of K+–H+ exchange (KHE), the LETM1… 
Highly Cited
2010
Highly Cited
2010
A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome.
Human Wolf-Hirschhorn syndrome (WHS) is a multigenic disorder resulting from a hemizygous deletion on chromosome 4. LETM1 is the… 
Highly Cited
2009
Highly Cited
2009
Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter
In and Out For over 40 years, Ca2+/H+ antiport has been reported across plasma cell membranes and mitochondrial inner membranes… 
Highly Cited
2009
Highly Cited
2009
Genome-Wide RNAi Screen Identifies Letm 1 as a Mitochondrial Ca 2 + / H + Antiporter
www.sciencemag.org (this information is current as of October 6, 2009 ): The following resources related to this article are… 
Highly Cited
2008
Highly Cited
2008
Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L
LETM1 is located in the chromosomal region that is deleted in patients suffering Wolf-Hirschhorn syndrome; it encodes a homolog… 
Highly Cited
2007
Highly Cited
2007
LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability.
Wolf-Hirschhorn syndrome (WHS) is a complex congenital syndrome caused by a monoallelic deletion of the short arm of chromosome 4… 
Highly Cited
2004
Highly Cited
2004
The LETM1/YOL027 Gene Family Encodes a Factor of the Mitochondrial K+ Homeostasis with a Potential Role in the Wolf-Hirschhorn Syndrome*
The yeast open reading frames YOL027 and YPR125 and their orthologs in various eukaryotes encode proteins with a single predicted… 
Highly Cited
1999
Highly Cited
1999
LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients.
Deletions within human chromosome 4p16.3 cause Wolf-Hirschhorn syndrome (WHS), which is characterized by severe mental and… 
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