Epstein-Barr virus and cellular DNA damage response

  title={Epstein-Barr virus and cellular DNA damage response},
  author={Nenad Sejic},
EBV is an oncogenic human gammaherpesvirus which infects B lymphocytes and epithelial cells. New virus replication occurs in both cell types and EBV encodes proteins to replicate its own DNA. Selective activation of the DNA damage response (DDR) is thought to occur in order for the virus to efficiently conserve its DNA sequence. Components of the double strand break homologous repair pathway are known to be recruited to viral replication compartments and loaded onto viral DNA to achieve… CONTINUE READING