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LEF1 gene

Known as: TCF1ALPHA, LEF1, TCF7L3 
This gene plays a role in both signal transduction and transcription.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis. The mechanisms that confer… Expand
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Highly Cited
2006
Highly Cited
2006
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele… Expand
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Highly Cited
2002
Highly Cited
2002
Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the formation of organs that depend on… Expand
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Highly Cited
2001
Highly Cited
2001
In skin, multipotent stem cells generate the keratinocytes of the epidermis, sebaceous gland, and hair follicles. In this paper… Expand
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Highly Cited
2001
Highly Cited
2001
The Wnt-responsive transcription factor LEF1 can activate transcription in association with beta-catenin and repress… Expand
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Highly Cited
2000
Highly Cited
2000
During mammalian tooth development, the oral ectoderm and mesenchyme coordinate their growth and differentiation to give rise to… Expand
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Highly Cited
2000
Highly Cited
2000
Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the… Expand
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Highly Cited
1999
Highly Cited
1999
Members of the LEF-1/TCF family of transcription factors have been implicated in the transduction of Wnt signals. However… Expand
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Highly Cited
1999
Highly Cited
1999
LEF/TCF DNA-binding proteins act in concert with activated beta -catenin, the product of Wnt signaling, to transactivate… Expand
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Highly Cited
1996
Highly Cited
1996
Targeted inactivation of the murine gene encoding the transcription factor LEF-1 abrogates the formation of organs that depend on… Expand
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