Skip to search formSkip to main contentSkip to account menu

LEF1 gene

Known as: TCF1ALPHA, LEF1, TCF7L3 
This gene plays a role in both signal transduction and transcription.
National Institutes of Health

Related topics

Related topics

9 relations
Cell Differentiation processCell Proliferation Regulatory ProcessChemotaxisHistone Acetylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Long noncoding RNA LEF1‐AS1 silencing suppresses the initiation and development of prostate cancer by acting as a molecular sponge of miR‐330‐5p via LEF1 repression
Prostate cancer (PCa) is one of the major cancers affecting males with high mortality around the world. Recent studies have found… 
2018
2018
Epstein-Barr virus stably confers an invasive phenotype to epithelial cells through reprogramming of the WNT pathway
Epstein-Barr virus (EBV)-associated carcinomas, such as nasopharyngeal carcinoma (NPC), exhibit an undifferentiated and… 
2016
2016
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors*
Hematopoietic and leukemic stem cells (HSCs and LSCs) have self-renewal ability to maintain normal hematopoiesis and leukemia… 
2016
2016
Elp 3 links tRNA modification to IRES-dependent translation of LEF 1 to sustain metastasis in breast cancer
The Rockefeller University Press $30.00 J. Exp. Med. 2016 Vol. 213 No. 11 2503–2523 https://doi.org/10.1084/jem.20160397 2503 INT… 
2014
2014
Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma.
Highly Cited
2011
Highly Cited
2011
Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer
Astrocyte-elevated gene-1 (AEG-1) plays an important role in diverse cancers and its up-regulation is associated with poor… 
2010
2010
Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells.
Highly Cited
2009
Highly Cited
2009
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and… 
2007
2007
Transcriptional regulation of MMP13 by Lef1 in chondrocytes.
Highly Cited
1999
Highly Cited
1999
Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1).
Previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 (Lef1) gene is upregulated in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)