LEF1 gene

Known as: TCF1ALPHA, LEF1, TCF7L3 
This gene plays a role in both signal transduction and transcription.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
010203019902017

Papers overview

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2010
2010
To further unravel the molecular pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), we performed high-resolution array… (More)
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Highly Cited
2009
Highly Cited
2009
Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis. The mechanisms that confer… (More)
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Highly Cited
2007
Highly Cited
2007
Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone fail to induce leukaemia. To identify… (More)
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2006
2006
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele… (More)
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Highly Cited
2004
Highly Cited
2004
Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate… (More)
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Highly Cited
2002
Highly Cited
2002
Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the formation of organs that depend on… (More)
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Highly Cited
2001
Highly Cited
2001
The Wnt-responsive transcription factor LEF1 can activate transcription in association with beta-catenin and repress… (More)
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Highly Cited
2000
Highly Cited
2000
Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the… (More)
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Highly Cited
2000
Highly Cited
2000
Recent evidence suggests that certain LEF/TCF family members act as repressors in the absence of Wnt signaling. We show here that… (More)
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Highly Cited
1995
Highly Cited
1995
We have studied the mechanism of delta 1-crystallin gene activation, which occurs early in lens cell differentiation, and have… (More)
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