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LE-SN38

Known as: Liposome entrapped 7-ethyl-10-hydroxycamptothecin, Liposome entrapped SN38, liposomal SN38 
The liposomal formulation of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically active metabolite of the prodrug irinotecan, with potential… 
National Institutes of Health

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Related topics

2 relations
NCIt Antineoplastic Agent Terminologyirinotecan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy
7-Ethyl-10-hydroxy camptothecin (SN38) is a potent topoisomerase inhibitor and a metabolite of irinotecan. Its clinical… 
2016
2016
Self-assembled nanoparticles comprising aptide–SN38 conjugates for use in targeted cancer therapy
Self-assembled nanoparticles (NPs) have been intensively utilized as cancer drug delivery carriers because hydrophobic anticancer… 
2015
2015
Interactions of nitroxide radicals with dendrimer-entrapped Au8-clusters: a fluorescent nanosensor for intracellular imaging of ascorbic acid.
When gold nanoparticles (AuNPs) become extremely small (<2 nm in diameter) as gold nanoclusters (AuNCs), an intriguing issue is… 
2013
2013
Abstract LB-159: A Phase I study of IMMU-130 (labetuzumab-SN38) anti-CEACAM5 antibody-drug conjugate (ADC) in patients with metastatic colorectal cancer (mCRC).
Background: IMMU-130 is an ADC comprising the humanized monoclonal IgG antibody (mAb), hMN-14 (labetuzumab), bound to the active… 
2013
2013
Preclinical antitumor activity of a nanoparticulate SN38
SummaryThe present studies were carried out to examine the efficacy of a nanoparticulate formulation of SN38, the potent… 
2007
2007
Involvement of Up-Regulation of Hepatic Breast Cancer Resistance Protein in Decreased Plasma Concentration of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Coadministration of S-1 in Rats
The safety and efficacy of combination therapy with 7-ethyl-10-[4-[1-piperidino]-1-piperidino]carbonyloxycamptothecin (CPT-11… 
2004
2004
Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence.
1995
1995
Leishmania donovani: pilot study for evaluation of therapeutic effects of inosine analogs against amastigotes in vitro and in vivo.
The inhibition of carbocyclic inosine (C-Ino), 3'-deoxyinosine (3'-dI), and 3'-fluoroinosine (3'-FI) to Leishmania donovani… 
1995
1995
Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous…
Irinotecan (CPT-11) is a camptothecin derivative used for the treatment of cancer. It is a prodrug that is metabolized to its… 
1987
1987
In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate
SummaryIt is shown in the present study that RAW 264 tumor cells can be killed by liposomeentrapped dichloromethylene… 
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