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LE-SN38

Known as: Liposome entrapped 7-ethyl-10-hydroxycamptothecin, Liposome entrapped SN38, liposomal SN38 
The liposomal formulation of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically active metabolite of the prodrug irinotecan, with potential… 
National Institutes of Health

Related topics

Related topics

2 relations
NCIt Antineoplastic Agent Terminologyirinotecan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Targeting Colorectal Cancer Stem-Like Cells with Anti-CD133 Antibody-Conjugated SN-38 Nanoparticles.
Cancer stem-like cells play a key role in tumor development, and these cells are relevant to the failure of conventional… 
2016
2016
Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin
Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a… 
Highly Cited
2013
Highly Cited
2013
Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: in vitro and in vivo studies.
Highly Cited
2011
Highly Cited
2011
G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.
Highly Cited
2011
Highly Cited
2011
CD44-targeting for antitumor drug delivery: a new SN-38-hyaluronan bioconjugate for locoregional treatment of peritoneal carcinomatosis.
An innovative approach for cancer therapy implies the use of drugs covalently conjugated to macromolecular carriers that… 
Highly Cited
2011
Highly Cited
2011
Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the Therapy of Hematologic Malignancies
We previously found that slowly internalizing antibodies conjugated with SN-38 could be used successfully when prepared with a… 
Highly Cited
2009
Highly Cited
2009
CEACAM5-Targeted Therapy of Human Colonic and Pancreatic Cancer Xenografts with Potent Labetuzumab-SN-38 Immunoconjugates
Purpose: To improve the efficacy and reduce the gastrointestinal toxicity of the cancer prodrug, CPT-11, we have developed… 
Highly Cited
2005
Highly Cited
2005
Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins
PurposeThe multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphate (ATP)-binding cassette… 
Highly Cited
2002
Highly Cited
2002
Intestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea.
The therapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the induction of severe late… 
Highly Cited
1999
Highly Cited
1999
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.
7-Ethyl-10-hydroxycamptothecin (SN-38) is a very promising anticancer drug used for the treatment of metastatic colonrectal… 
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