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LAT2 gene

Known as: LINKER FOR ACTIVATION OF B CELLS, linker for activation of T cells, transmembrane adaptor 2, WSCR5 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho
The transmembrane adaptor protein NTAL (non‐T‐cell activation linker) participates in signalosome assembly in hematopoietic cells… 
Review
2008
Review
2008
Progress in allergy signal research on mast cells: signal regulation of multiple mast cell responses through FcepsilonRI.
The crosslinking of FcepsilonRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic… 
2007
2007
Regulation of Ca2+ Signaling in Mast Cells by Tyrosine-Phosphorylated and Unphosphorylated Non-T Cell Activation Linker1
Engagement of the FcεRI in mast cells and basophils leads to a rapid tyrosine phosphorylation of the transmembrane adaptors LAT… 
2007
2007
Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells.
2006
2006
Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor.
Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid… 
Highly Cited
2005
Highly Cited
2005
Cholesterol depletion inhibits src family kinase‐dependent calcium mobilization and apoptosis induced by rituximab crosslinking
The monoclonal antibody (mAb) rituximab produces objective clinical responses in patients with B‐cell non‐Hodgkin's lymphoma and… 
Highly Cited
2005
Highly Cited
2005
Single and Combined Deletions of the NTAL/LAB and LAT Adaptors Minimally Affect B-Cell Development and Function
ABSTRACT NTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily… 
Review
2005
Review
2005
NTAL/LAB and LAT: a balancing act in mast-cell activation and function.
Highly Cited
2004
Highly Cited
2004
Linker for Activation of B Cells: A Functional Equivalent of a Mutant Linker for Activation of T Cells Deficient in Phospholipase C-γ1 Binding1
Adaptor proteins have important functions in coupling stimulation through immunoreceptors with downstream events. The adaptor… 
2004
2004
The Importance of Three Membrane-distal Tyrosines in the Adaptor Protein NTAL/LAB*
NTAL (non-T cell activation linker)/LAB (linker for activation of B cells) is a LAT (linker for activation of T cells)-like… 
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