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L 739749

Known as: L-739,749, L-739749 
National Institutes of Health

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1 relation

Broader (1)

Oligopeptides

Papers overview

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2005
2005
Resistance of K-RasBVl 2 proteins to farnesyltransferase inhibitors in Ratl cells ( protein prenylation / geranylgeranyl transferase I / transformed cells / benzodiazepine-5 B / L-739 , 749 )
Benzodiazepine (BZA)-5B, a CAAX farnesyltransferase inhibitor, was previously shown to block the farnesylation of H-Ras and to… 
Highly Cited
2000
Highly Cited
2000
Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors.
Juvenile myelomonocytic leukemia (JMML) is an early childhood disease for which there is no effective therapy. Therapy with 13… 
Highly Cited
1997
Highly Cited
1997
Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB*
Protein farnesyltransferase inhibitors (FTIs) inhibit Ras transformation and Ras-dependent tumor cell growth, but the biological… 
Highly Cited
1996
Highly Cited
1996
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to… 
1996
1996
Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.
Pharmacological inhibitors of the housekeeping enzyme farnesyl transferase (FT) inhibit the growth of ras-transformed cells in… 
1996
1996
Inhibitors of anchorage-independent growth affect the growth of transformed cells on poly(2-hydroxyethyl methacrylate)-coated surfaces.
We have described a microplate colorimetric assay to quantitate anchorage-independent cell growth, using plates coated with an… 
1996
1996
Inhibitors of anchorage‐independent growth affect the growth of transformed cells on poly(2‐hydroxyethyl methacrylate)‐coated surfaces
We have described a microplate colorimetric assay to quantitate anchorage‐independent cell growth, using plates coated with an… 
Highly Cited
1995
Highly Cited
1995
Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
Small-molecule inhibitors of the housekeeping enzyme farnesyltransferase (FT) suppress the malignant growth of Ras-transformed… 
Highly Cited
1994
Highly Cited
1994
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell… 
Highly Cited
1994
Highly Cited
1994
Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
A potent and specific small molecule inhibitor of farnesyl-protein transferase, L-739,749, caused rapid morphological reversion… 
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