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L 739749

Known as: L-739,749, L-739749 
 
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
Juvenile myelomonocytic leukemia (JMML) is an early childhood disease for which there is no effective therapy. Therapy with 13… Expand
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Highly Cited
1997
Highly Cited
1997
Protein farnesyltransferase inhibitors (FTIs) inhibit Ras transformation and Ras-dependent tumor cell growth, but the biological… Expand
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Highly Cited
1996
Highly Cited
1996
Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to… Expand
Highly Cited
1996
Highly Cited
1996
Pharmacological inhibitors of the housekeeping enzyme farnesyl transferase (FT) inhibit the growth of ras-transformed cells in… Expand
1996
1996
We have described a microplate colorimetric assay to quantitate anchorage-independent cell growth, using plates coated with an… Expand
1996
1996
We have described a microplate colorimetric assay to quantitate anchorage‐independent cell growth, using plates coated with an… Expand
Highly Cited
1995
Highly Cited
1995
The growth of solid tumors in vivo beyond 1-2 mm in diameter requires induction and maintenance of an angiogenic response. This… Expand
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Highly Cited
1995
Highly Cited
1995
Small-molecule inhibitors of the housekeeping enzyme farnesyltransferase (FT) suppress the malignant growth of Ras-transformed… Expand
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Highly Cited
1994
Highly Cited
1994
The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell… Expand
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Highly Cited
1994
Highly Cited
1994
A potent and specific small molecule inhibitor of farnesyl-protein transferase, L-739,749, caused rapid morphological reversion… Expand