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L-735 524

Known as: L 735 524, L 735,524, L735 524 
National Institutes of Health

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2 relations

Broader (2)

IndinavirIndinavir Sulfate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of… 
Highly Cited
2000
Highly Cited
2000
Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
Three new peptidomimetics (1-3) have been developed with highly stable and conformationally constrained macrocyclic components… 
2000
2000
Comparative in vitro metabolism of indinavir in primates - a unique stereoselective hydroxylation in monkey
1. The in vitro metabolism of indinavir (CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, was evaluated using liver… 
2000
2000
Identifying and Characterizing HIV Protease Inhibitors.
HIV protease catalyzes the hydrolysis of specific peptide bonds of viral polyproteins, thus processing these polyproteins into… 
1998
1998
Molecular mechanisms of resistance: Free energy calculations of mutation effects on inhibitor binding to HIV‐1 protease
The changes in the inhibitor binding constants due to the mutation of isoleucine to valine at position 84 of HIV‐1 protease are… 
1997
1997
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.
1997
1997
In vitro metabolism of indinavir in the human fetal liver microsomes.
In vitro microsomal formation of primary metabolites of indinavir (CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, were… 
1996
1996
Polymer-based solvents for minimizing pollution during the synthesis of fine chemicals
Most processes used in the pharmaceutical industry are, by necessity, carried out in organic solvents. In many cases these… 
1995
1995
Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs
AbstractPurpose. To evaluate regional intestinal absorption and the feasibility of sustained release dosage form development for… 
1995
1995
Merck protease inhibitor available to persons with CD4 count 50 or less--must register by August 11.
Merck & Co. has announced an expanded-access program to make Crixivan (generic name, indinavir sulfate), its experimental… 
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