Skip to search formSkip to main contentSkip to account menu

L 731988

Known as: L 731,988, L-731,988, L-731988 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AcetoacetatesPyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
2007
2007
Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker
Based on the prodrug concept as well as the combination of two different classes of anti-HIV agents, we have designed and… 
Highly Cited
2006
Highly Cited
2006
Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by α-Hydroxytropolones
Integration is a crucial step in the life cycle of human immunodeficiency virus type 1 (HIV-1); therefore, inhibitors of HIV-1… 
2006
2006
Preliminary Mapping of a Putative Inhibitor-Binding Pocket for Human Immunodeficiency Virus Type 1 Integrase Inhibitors
ABSTRACT Molecular modeling studies have identified a putative human immunodeficiency virus (HIV) integrase (IN) inhibitor… 
2005
2005
Diketoacid HIV-1 integrase inhibitors: An ab initio study.
The stable tautomeric forms of two representative arene-substituted diketoacid HIV-1 integrase inhibitors, 5-ClTEP and L-731,988… 
Review
2004
Review
2004
Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Diketo acids such as S-1360 (1A) and L-731,988 (2) are potent and selective inhibitors of HIV-1 integrase (IN). A plethora of… 
2002
2002
Structure-based Design of a Novel Peptide Inhibitor of HIV-1 Integrase: A Computer Modeling Approach
Abstract The insertion of viral DNA into the host chromosome is an essential step in the replication of HIV-1, and is carried out… 
2001
2001
Specific Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Integration in Cell Culture: Putative Inhibitors of HIV-1 Integrase
ABSTRACT To study the effect of potential human immunodeficiency virus type 1 (HIV-1) integrase inhibitors during virus… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)