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L 694,458

Known as: L 694458, L-694,458, L-694458 
National Institutes of Health

Related topics

Related topics

2 relations
DMP 777

Broader (1)

piperazine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
Current synthetic inhibitors of human neutrophil elastase
The imbalance between human neutrophil elastase (HNE, EC 3.4.21.37) and endogenous antiproteinases is considered to cause various… 
Review
2002
Review
2002
Neutrophil elastase inhibitors as treatment for COPD
Chronic obstructive pulmonary disease, characterised by a slowly progressive, irreversible airways limitation, is a major… 
1998
1998
Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching.
1997
1997
Orally active inhibitors of human leukocyte elastase. II. Disposition of L-694,458 in rats and rhesus monkeys.
The disposition of L-694,458, a potent monocyclic beta-lactam inhibitor of human leukocyte elastase, was studied in male Sprague… 
1997
1997
Orally active inhibitors of human leukocyte elastase. III. Identification and characterization of metabolites of L-694,458 by liquid chromatography-tandem mass spectrometry.
The in vitro and in vivo metabolism of N-[1(R)-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2(S)-[4-[(4-methy l-1-piperazinyl… 
Highly Cited
1996
Highly Cited
1996
An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters.
A convergent synthesis of [S-(R,S)]-2-[4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy]-3,3-diethyl-N-[1-[3,4-(methylenedioxy)phenyl… 
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