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L 685818

Known as: 15,19-Epoxy-(3H)-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,11R*,12S*,14R*,15S*,16R*,18S*,19S*,26aR*))-, L-685,818, L 685,818 
National Institutes of Health

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2 relations

Broader (1)

Tacrolimus
analogs & derivatives

Papers overview

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Review
2005
Review
2005
FKBPI2 Is Not Required for the Modulation of Transforming Growth Factor fi Receptor I Signaling Activity in Embryonic Fibroblasts and Thymocytes1
Transforming growth factor 1 (TGF-fi) signals through a heteromenc complex of type I and type II transmembrane senne-threonine… 
1996
1996
Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.
Proliferation of the BJAB B-lymphoblastoid cell line was rapidly and almost completely suppressed by picomolar concentrations of… 
1995
1995
Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin.
The expression of CD5 can be induced on murine B-2 cells by anti-IgM, a recognized analog of thymus-independent 2 type (TI-2… 
1995
1995
Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by rapamycin in a T cell lymphoma.
The immunosuppressive macrolide, rapamycin, impedes the G1 to S cell cycle progression in cytokine-stimulated normal lymphocytes… 
Highly Cited
1994
Highly Cited
1994
FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
L-685,818 differs only slightly in structure from the immunosuppressive drug FK-506, and both compounds bind with comparable… 
Highly Cited
1993
Highly Cited
1993
Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.
The protein phosphatase calcineurin is the putative target for the immunosuppressive drug FK-506. The enzyme is inhibited by the… 
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