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L 685818

Known as: 15,19-Epoxy-(3H)-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,11R*,12S*,14R*,15S*,16R*,18S*,19S*,26aR*))-, L-685,818, L 685,818 
 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Azoles target the ergosterol biosynthetic enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal… Expand
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2003
2003
BIG1 and BIG2 are brefeldin A-inhibited guanine nucleotide-exchange proteins that activate ADP-ribosylation factors (ARFs… Expand
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Highly Cited
2000
Highly Cited
2000
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening infections of the central nervous system… Expand
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Highly Cited
1998
Highly Cited
1998
Micelles formed from polycaprolactone-b-poly(ethylene oxide) (PCL-b-PEO) diblock copolymers were investigated as a novel drug… Expand
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Highly Cited
1997
Highly Cited
1997
We show that the nonimmunosuppressive analogues of the immunosuppressive drugs FK506, rapamycin and cyclosporin A promote neurite… Expand
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Highly Cited
1997
Highly Cited
1997
The immunosuppressant FK506 (tacrolimus) is an antifungal natural product macrolide that suppresses the immune system by blocking… Expand
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1995
1995
Macrophage infectivity potentiators are membrane proteins described as virulence factors in bacterial intracellular parasites… Expand
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1993
1993
The protein phosphatase calcineurin is the putative target for the immunosuppressive drug FK-506. The enzyme is inhibited by the… Expand
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1993
1993
L-685,818 differs only slightly in structure from the immunosuppressive drug FK-506, and both compounds bind with comparable… Expand
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Highly Cited
1992
Highly Cited
1992
FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant… Expand
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