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L 685818

Known as: 15,19-Epoxy-(3H)-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,11R*,12S*,14R*,15S*,16R*,18S*,19S*,26aR*))-, L-685,818, L 685,818 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
ABSTRACT Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal… Expand
2003
2003
BIG1 and BIG2 are brefeldin A-inhibited guanine nucleotide-exchange proteins that activate ADP-ribosylation factors (ARFs… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening infections of the central… Expand
Highly Cited
1998
Highly Cited
1998
Micelles formed from polycaprolactone-b-poly(ethylene oxide) (PCL-b-PEO) diblock copolymers were investigated as a novel drug… Expand
Highly Cited
1997
Highly Cited
1997
We show that the nonimmunosuppressive analogues of the immunosuppressive drugs FK506, rapamycin and cyclosporin A promote neurite… Expand
Highly Cited
1997
Highly Cited
1997
The immunosuppressant FK506 (tacrolimus) is an antifungal natural product macrolide that suppresses the immune system by blocking… Expand
Highly Cited
1995
Highly Cited
1995
Macrophage infectivity potentiators are membrane proteins described as virulence factors in bacterial intracellular parasites… Expand
Highly Cited
1993
Highly Cited
1993
The protein phosphatase calcineurin is the putative target for the immunosuppressive drug FK-506. The enzyme is inhibited by the… Expand
Highly Cited
1993
Highly Cited
1993
L-685,818 differs only slightly in structure from the immunosuppressive drug FK-506, and both compounds bind with comparable… Expand
Highly Cited
1992
Highly Cited
1992
FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant… Expand
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