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Ketolides

Known as: 3-Keto Erythromycins, Erythromycins, 3-Keto, 3-Keto-Erythromycins 
Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes. Transporter-mediated uptake of drugs… Expand
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Highly Cited
2003
Highly Cited
2003
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT A total of 1,531 recent clinical isolates of Streptococcus pneumoniae were collected from 33 medical centers nationwide… Expand
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Highly Cited
2001
Highly Cited
2001
Macrolides represent a clinically important class of antibiotics that block protein synthesis by interacting with the large… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT In this study (1998–1999), we collected 215 macrolide-resistantStreptococcus pneumoniae isolates from an ongoing… Expand
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Review
2000
Review
2000
  • A. Bryskier
  • Clinical microbiology and infection : the…
  • 2000
  • Corpus ID: 41864659
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A… Expand
Highly Cited
1999
Highly Cited
1999
Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide‐binding site on the ribosome, a… Expand
Highly Cited
1999
Highly Cited
1999
In the search for new ketolides with improved activities against erythromycin-resistant S. pneumoniae and H. influenzae we… Expand
Highly Cited
1998
Highly Cited
1998
In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new… Expand
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Highly Cited
1997
Highly Cited
1997
Ketolides belong to a new class of semi-synthetic 14-membered-ring macrolides, which differ from erythromycin A by having a 3… Expand
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