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Ketolides

Known as: 3-Keto Erythromycins, Erythromycins, 3-Keto, 3-Keto-Erythromycins 
Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.
National Institutes of Health

Papers overview

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Review
2012
Review
2012
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory… 
Review
2002
Review
2002
Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance… 
Review
2001
Review
2001
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macrolide, erythromycin A. The main… 
Review
2001
Review
2001
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory… 
Highly Cited
2001
Highly Cited
2001
ABSTRACT In this study (1998–1999), we collected 215 macrolide-resistantStreptococcus pneumoniae isolates from an ongoing… 
Review
2000
Review
2000
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A… 
Highly Cited
1999
Highly Cited
1999
Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide‐binding site on the ribosome, a… 
Highly Cited
1998
Highly Cited
1998
In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new… 
Highly Cited
1997
Highly Cited
1997
Ketolides belong to a new class of semi-synthetic 14-membered-ring macrolides, which differ from erythromycin A by having a 3…