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Ketolides

Known as: 3-Keto Erythromycins, Erythromycins, 3-Keto, 3-Keto-Erythromycins 
Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.
National Institutes of Health

Papers overview

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Review
2009
Review
2009
The advanced macrolides, azithromycin and clarithromycin, and the ketolide, telithromycin, are structural analogs of erythromycin… Expand
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Highly Cited
2007
Highly Cited
2007
Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes. Transporter-mediated uptake of drugs… Expand
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Review
2006
Review
2006
Until recently, cardiac toxicity manifesting in the form of arrhythmias related to QT interval prolongation was uncommonly… Expand
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Highly Cited
2003
Highly Cited
2003
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated… Expand
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Highly Cited
2001
Highly Cited
2001
A total of 1,531 recent clinical isolates of Streptococcus pneumoniae were collected from 33 medical centers nationwide during… Expand
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Highly Cited
2001
Highly Cited
2001
Macrolides represent a clinically important class of antibiotics that block protein synthesis by interacting with the large… Expand
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Review
2000
Review
2000
  • André Bryskier
  • Clinical microbiology and infection : the…
  • 2000
  • Corpus ID: 41864659
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A… Expand
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Highly Cited
1999
Highly Cited
1999
Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide-binding site on the ribosome, a… Expand
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Highly Cited
1997
Highly Cited
1997
Ketolides belong to a new class of semi-synthetic 14-membered-ring macrolides, which differ from erythromycin A by having a 3… Expand
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Review
1997
Review
1997
Mycoplasmas are the smallest free-living microorganisms, being about 300 nm in diameter. They are bounded by a triple-layered… Expand
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