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KYNU GENE

Known as: KYNU, KYNURENINASE, L-kynurenine hydrolase 
National Institutes of Health

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Kynureninase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.
The kynurenine pathway (KP) of L-tryptophan metabolism produces several neuroactive metabolites with an amino acid structure… 
Review
2015
Review
2015
Understanding the role of the kynurenine pathway in human breast cancer immunobiology
Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide… 
Highly Cited
2013
Highly Cited
2013
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
Immunological tolerance to self-antigen impairs humoral responses to HIV-1. 
Highly Cited
2003
Highly Cited
2003
Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase.
Highly Cited
1996
Highly Cited
1996
Kynurenine Disposition in Blood and Brain of Mice: Effects of Selective Inhibitors of Kynurenine Hydroxylase and of Kynureninase
Abstract: To study the regulation of the synthesis of quinolinic and kynurenic acids in vivo, we evaluated (a) the metabolism of… 
Highly Cited
1995
Highly Cited
1995
Comparison of the Neurochemical and Behavioral Effects Resulting from the Inhibition of Kynurenine Hydroxylase and/or Kynureninase
Abstract: Several kynurenine analogues were synthesized and tested as inhibitors of the enzymes kynurenine hydroxylase and/or… 
Highly Cited
1994
Highly Cited
1994
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities
Highly Cited
1994
Highly Cited
1994
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
The synthesis of (o-nitrobenzoyl)-, (m-nitrobenzoyl)-, and (p-nitrobenzoyl)alanine (o-, m-, and p-NBA), three new kynurenine… 
Highly Cited
1993
Highly Cited
1993
Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia
Abstract: Delayed increases in the levels of an endogenous N‐methyl‐D‐aspartate receptor agonist, quinolinic acid (QUIN), have… 
Highly Cited
1962
Highly Cited
1962
Kynurenine-transaminase, kynureninase and the increase of xanthurenic acid excretion.
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